Protein Degradation: Ubiquitin and the Chemistry of Life, Volume 1

Protein Degradation: Ubiquitin and the Chemistry of Life, Volume 1

Editor(s): R. John Mayer, Aaron Ciechanover, Martin Rechsteiner

Published Online: 18 NOV 2005

Print ISBN: 9783527308378

Online ISBN: 9783527605866

DOI: 10.1002/352760586X

About this Book

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway.
The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series,
and Avram Hershko has contributed to the opening chapter of the present volume.
Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes.
Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Table of contents

    1. You have free access to this content
    2. Chapter 10

      Molecular Machines for Protein Degradation (pages 248–287)

      Matthias Bochtler, Michael Groll, Hans Brandstetter, Tim Clausen and Robert Huber

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