Leukocyte Trafficking: Molecular Mechanisms, Therapeutic Targets, and Methods

Copyright © 2005 Wiley-VCH Verlag GmbH & Co. KGaA

Leukocyte Trafficking: Molecular Mechanisms, Therapeutic Targets, and Methods

Editor(s): Alf Hamann, Britta Engelhardt

Published Online: 22 MAY 2006

Print ISBN: 9783527312283

Online ISBN: 9783527607792

DOI: 10.1002/352760779X

About this Book

Product Information

About The Product

Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo.
The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XXII)

    1. You have free access to this content
      Color Plates (pages XXV–XL)

  3. Part I: Molecular Mechanisms

    1. Chapter 1

      The Multistep Model of Leukocyte Trafficking: A Personal Perspective from 15 Years Later (pages 1–13)

      Eugene C. Butcher

    2. Chapter 2

      Capture and Rolling: Selectins and Their Ligands (pages 14–35)

      Claudine S. Bonder and Paul Kubes

    3. Chapter 3

      Chemokines and Their Receptors: Biochemical, Structural and Biological Properties (pages 36–67)

      Martin Oppermann and Reinhold Förster

    4. Chapter 4

      Mechanisms of Leukocyte Integrin Activation (pages 68–81)

      Gabriela Constantin and Carlo Laudanna

    5. Chapter 5

      Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules (pages 82–108)

      Federica M. Marelli-Berg and Sussan Nourshargh

    6. Chapter 6

      The Endothelial Cell Basement Membrane and Its Role in Leukocyte Extravasation (pages 109–127)

      Lydia M. Sorokin

  4. Part II: Trafficking in vivo

    1. Chapter 7

      Control of Homing Receptor Expression during Lymphocyte Differentiation, Activation, and Function (pages 129–153)

      Daniel J. Campbell

    2. Chapter 8

      Trafficking of Lymphocyte Subpopulations (pages 154–172)

      Alf Hamann, Carrie N. Arnold and Gudrun F. Debes

    3. Chapter 9

      Trafficking of B Cells (pages 173–183)

      Rudolf A. Manz

    4. Chapter 10

      Trafficking of Dendritic Cells (pages 184–215)

      Nikolaus Romani, Sandra Holzmann, Christoph H. Tripp, Michael Sixt and Patrizia Stoitzner

  5. Part III: Inflammation

    1. Chapter 11

      Molecular and Cellular Contributions to Selectin-Dependent Leukocyte Adhesion Under Flow (pages 218–247)

      Rodger P. McEver

    2. Chapter 12

      Mechanisms of Inflammation: Neutrophils (pages 248–268)

      Markus Sperandio and Barbara Walzog

    3. Chapter 13

      Chemokines Drive Inflammatory Leukocyte Recruitment (pages 269–299)

      Stefan Floess and Antal Rot

    4. Chapter 14

      Mechanism of Inflammation: Activation of the Endothelium (pages 300–335)

      Matthias Clauss and Carolyn E. Patterson

  6. Part IV: Trafficking Mechanisms as Therapeutic Targets

    1. Chapter 15

      Integrins as Therapeutic Targets for Inflammatory Disease (pages 338–370)

      Michael J. Briskin

    2. Chapter 16

      Chemokine Receptor Antagonists: From the Bench to the Clinic (pages 371–402)

      Sofia Ribeiro and Richard Horuk

  7. Part V: Methods to Study Cell Trafficking

    1. Chapter 17

      Leukocyte–Endothelial Cell–Cell Interactions in Vitro: Static Assays and Adhesion under Shear Stress (pages 404–417)

      Markus Hammel, Olaf Zilles, Rupert Hallmann, Silke Jennrich, Kerstin Siegmund and Alf Hamann

    2. Chapter 18

      Chemotaxis Assay: Analysis of Migration of Lymphocyte Subsets (pages 418–423)

      Kerstin Siegmund, Gudrun F. Debes and Alf Hamann

    3. Chapter 19

      In Vitro Transendothelial Migration Assay (pages 424–436)

      Ruth Lyck and Britta Engelhardt

    4. Chapter 20

      Real Time In Vitro Assays for Studying Leukocyte Transendothelial Migration Under Physiological Flow Conditions (pages 437–454)

      Ronen Alon, Guy Cinamon and Francis W. Luscinskas

    5. Chapter 21

      Intravital Microscopy and In Vitro Flow Chamber: Techniques to Study Leukocyte Adhesion Under Flow and in Real Time (pages 455–471)

      Jens V. Stein

    6. Chapter 22

      Immune Processes in the Light of Two-Photon Microscopy (pages 472–496)

      Alexander Flügel and Naoto Kawakami

    7. Chapter 23

      Use of Labeled Lymphocytes to Analyze Trafficking In Vivo (pages 497–508)

      Kerstin Siegmund and Alf Hamann

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      Index (pages 509–517)

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