Nutritional Genomics: Impact on Health and Disease

Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA

Nutritional Genomics: Impact on Health and Disease

Editor(s): Regina Brigelius-Flohé, Hans-Georg Joost

Published Online: 29 JUN 2006

Print ISBN: 9783527312948

Online ISBN: 9783527608102

DOI: 10.1002/3527608109

About this Book

Product Information

About The Product

Nutritional genomics paves the way for novel applications in medicine and human nutrition, and this volume presents the latest data on how genetic variation is associated with dietary response and how nutrients influence gene expression. In so doing, it brings together the various disciplines involved in this field of research, making this essential reading for nutritionists, biochemists and molecular biologists.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XXVIII)

  2. Part I: Introduction – Definitions

    1. Chapter 1

      Nutritional Genomics: Concepts, Tools and Expectations (pages 2–21)

      Hannelore Daniel and Uwe Wenzel

  3. Part II: Nutrigenomics (Nutrient–Gene Interactions)

    1. Chapter 2

      Nuclear Receptors: An Overview (pages 24–47)

      Ana Aranda and Angel Pascual

    2. Chapter 3

      Mechanism of Action and Cancer Therapeutic Potential of Retinoids (pages 49–73)

      Emilie Voltz, Emmanuelle Germain and Hinrich Gronemeyer

    3. Chapter 4

      Nuclear Receptors and the Control of Gene Expression by Fatty Acids (pages 74–91)

      Jean-Paul Pégorier

    4. Chapter 5

      Cellular Adaptation to Amino Acid Availability: Mechanisms Involved in the Regulation of Gene Expression (pages 92–105)

      Alain Bruhat, Anne-Catherine Maurin, Céline Jousse, Yoan Cherasse and Pierre Fafournoux

    5. Chapter 6

      Transcriptional Regulation of Hepatic Genes by Insulin and Glucose (pages 106–116)

      Catherine Postic and Fabienne Foufelle

    6. Chapter 7

      PPARs: Lipid Sensors that Regulate Cell Differentiation Processes (pages 117–131)

      Frédéric Varnat, Liliane Michalik, Béatrice Desvergne and Walter Wahli

    7. Chapter 8

      Advances in Selenoprotein Expression: Patterns and Individual Variations (pages 132–158)

      Catherine Méplan, Vasileios Pagmantidis and John E. Hesketh

    8. Chapter 9

      PPARs in Atherosclerosis (pages 159–179)

      Hélène Duez, Jean-Charles Fruchart and Bart Staels

    9. Chapter 10

      Protein Synthesis and Cancer (pages 180–194)

      Andreas G. Bader and Peter K. Vogt

    10. Chapter 11

      Mutations in the PPARγ Gene Relevant for Diabetes and the Metabolic Syndrome (pages 195–207)

      Markku Laakso

    11. Chapter 12

      Regulation of Lipogenic Genes in Obesity (pages 208–219)

      Stéphane Mandard and Sander Kersten

  4. Part III: Nutrigenetics (Nutrient–Genotype Interactions)

    1. Chapter 13

      The Genetics of Type 2 Diabetes (pages 222–265)

      Catherine Stevenson, Inês Barroso and Nicholas Wareham

    2. Chapter 14

      Gene Variants and Obesity (pages 266–299)

      Günter Brönner, A. Hinney, K. Reichwald, A.-K. Wermter, A. Scherag, S. Friedel and Johannes Hebebrand

    3. Chapter 15

      Gene Polymorphisms, Nutrition, and the Inflammatory Response (pages 300–326)

      Robert F. Grimble

    4. Chapter 16

      Gene Variants, Nutritional Parameters, and Hypertension (pages 327–354)

      Maolian Gong and Norbert Hübner

    5. Chapter 17

      Gene Variants, Nutrition, and Cancer (pages 355–385)

      Julian Little and Linda Sharp

    6. Chapter 18

      Taste Receptors and Their Variants (pages 386–411)

      Bernd Bufe and Wolfgang Meyerhof

    7. Chapter 19

      Cancer and Gene Variants in Enzymes Metabolizing Dietary Xenobiotics (pages 412–430)

      Susan Nowell and Fred F. Kadlubar

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      Index (pages 431–442)

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