Ligand Design for G Protein-coupled Receptors

Ligand Design for G Protein-coupled Receptors

Editor(s): Didier Rognan

Published Online: 6 JUN 2006

Print ISBN: 9783527312849

Online ISBN: 9783527608249

DOI: 10.1002/3527608249

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.
Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.
Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      Why G Protein-coupled Receptors Databases are Needed (pages 27–49)

      Jacques Haiech, Jean-Luc Galzi, Marie-Claude Kilhoffer, Marcel Hibert and Didier Rognan

    3. Chapter 3

      A Novel Drug Screening Assay for G Protein-coupled Receptors (pages 51–60)

      Brian F. O'Dowd, Xiaodong Ji, Mohammad Alijaniaram, Tuan Nguyen and Susan R. George

    4. Chapter 6

      Allosteric Properties and Regulation of G Protein-coupled Receptors (pages 99–113)

      Jean-Luc Galzi, Emeline Maillet, Sandra Lecat, Muriel Hachet-Haas, Jacques Haiech, Marcel Hibert and Brigitte Ilien

    5. Chapter 8

      Strategies for the Design of pGPCR-targeted Libraries (pages 137–164)

      Nikolay P. Savchuk, Sergey E. Tkachenko and Konstantin V. Balakin

    6. Chapter 10

      3-D Structure of G Protein-coupled Receptors (pages 183–203)

      Leonardo Pardo, Xavier Deupi, Cedric Govaerts and Mercedes Campillo

    7. Chapter 11

      7TM Models in Structure-based Drug Design (pages 205–239)

      Frank E. Blaney, Anna-Maria Capelli and Giovanna Tedesco

    8. You have free access to this content