Fragment-based Approaches in Drug Discovery

Fragment-based Approaches in Drug Discovery

Editor(s): Wolfgang Jahnke, Daniel A. Erlanson

Published Online: 28 AUG 2006

Print ISBN: 9783527312917

Online ISBN: 9783527608768

DOI: 10.1002/3527608761

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Table of contents

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  1. Part 1: Concept and Theory

    1. Chapter 2

      Multivalency in Ligand Design (pages 11–53)

      Vijay M. Krishnamurthy, Lara A. Estroff and George M. Whitesides

  2. Part 2: Fragment Library Design and Computional Approaches

  3. Part 3: Experimental Techniques and Applications

    1. Chapter 10

      Pyramid: An Integrated Platform for Fragment-based Drug Discovery (pages 193–214)

      Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams and Harren Jhoti

    2. Chapter 14

      Tethering (pages 285–310)

      Daniel A. Erlanson, Marcus D. Ballinger and James A. Wells

  4. Part 4: Emerging Technologies in Chemistry

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