Chirality in Drug Research, Volume 33

Chirality in Drug Research, Volume 33

Editor(s): Eric Francotte, Wolfgang Lindner

Published Online: 11 OCT 2006

Print ISBN: 9783527310760

Online ISBN: 9783527609437

DOI: 10.1002/3527609431

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Table of contents

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  1. Introduction

  2. Synthesis

    1. Chapter 3

      Aspects of Chirality in Natural Products Drug Discovery (pages 67–94)

      Philipp Krastel, Frank Petersen, Silvio Roggo, Esther Schmitt and Ansgar Schuffenhauer

  3. Separations

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