Textbook of in vivo Imaging in Vertebrates

Textbook of in vivo Imaging in Vertebrates

Editor(s): Vasilis Ntziachristos, Anne Leroy-Willig, Bertrand Tavitian

Published Online: 16 JUL 2007

Print ISBN: 9780470015285

Online ISBN: 9780470029596

DOI: 10.1002/9780470029596

About this Book

This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research.

Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates:

  • The types of information that can be obtained with modern in vivo imaging; 
  • The substitution of imaging methods for more destructive histological techniques; 
  • The advantages conferred by in vivo imaging in building a more accurate picture of the response of tissues to stimuli over time while significantly reducing the number of animals required for such studies.

Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy.

Most chapters are written by teams of physicists and biologists, giving a balanced coherent description of each technique and its potential applications. 

Table of contents

    1. You have free access to this content
    2. Chapter 3

      Ultrasound Imaging (pages 79–101)

      S. Lori Bridal, Jean-Michel Correas and Geneviève Berger

    3. Chapter 4

      In Vivo Radiotracer Imaging (pages 103–147)

      Bertrand Tavitian, Régine Trébossen, Roberto Pasqualini and Frédéric Dollé

    4. Chapter 6

      Optical Microscopy in Small Animal Research (pages 183–190)

      Rakesh K. Jain, Dai Fukumura, Lance Munn and Edward Brown

    5. Chapter 7

      New Radiotracers, Reporter Probes and Contrast Agents (pages 191–221)

      Bertrand Tavitian, Roberto Pasqualini, Frédéric Dollé, Willem J. M. Mulder, Gustav J. Strijkers, Klaas Nicolay, Benedict Law, Ching-Hsuan Tung, Silvio Aime, Huongfeng Li and Andreas H. Jacobs

    6. Chapter 8

      Multi-Modality Imaging (pages 223–232)

      Vasilis Ntziachristos, Fred S. Azar and Jan Grimm

    7. Chapter 9

      Brain Imaging (pages 233–256)

      Anne Leroy-Willig, Greet Vanhoutte, Annemie Van der Linden, Jet P. van der Zijden, Rick M. Dijkhuizen, Andrew K. Dunn, Vincent Van Meir, Wim Vanduffel, Koen Nelissen, Denis Fize, Guy A. Orban, Vincent Lebon and Philippe Hantraye

    8. Chapter 10

      Imaging of Heart, Muscle, Vessels (pages 257–275)

      Yves Fromes, Valérie Allamand, Kevin McCully, Urs Giger, Jörg. U. G. Streif, Matthias Nahrendorf, Wolfgang R. Bauer, F. Stuart Foster, Willem J. M. Mulder, Gustav J. Strijkers, Zahi A. Fayad and Klaas Nicolay

    9. Chapter 11

      Tumor Imaging (pages 277–309)

      Vasilis Ntziachristos, Charles André Cuénod, Laure Fournier, Daniel Balvay, Clément Pradel, Nathalie Siauve, Olivier Clement, Erwan Jouannot, Olivier Lucidarme, Silvana Del Vecchio, Marco Salvatore, Benedict Law, Ching-Hsuan Tung, Rakesh K. Jain, Dai Fukumura, Lance L. Munn, Edward B. Brown, Eyk Schellenberger, Xavier Montet, Ralph Weissleder, Nora De Clerck and Andrei Postnov

    10. Chapter 12

      Other Organs (pages 311–332)

      Anne Leroy-Willig, James Sharpe, Cyrus Papan, Russell E. Jacobs, Johann Le Floc'h, Nathalie Siauve, Laurent Salomon, Charles André Cuénod, Nicolas Grenier, Olivier Hauger, Yahsou Delmas, Christian Combe, Jodi Haller and Andreas Wunder

    11. Chapter 13

      Gene Therapy (pages 333–346)

      Markus Klein and Andreas H. Jacobs

    12. Chapter 14

      Cellular Therapies and Cell Tracking (pages 347–367)

      Yves Fromes, Michel Modo, Vít Herynek, Mathias Hoehn, Yannic Waerzeggers and Andreas H. Jacobs

    13. You have free access to this content