Sepsis: New Insights, New Therapies: Novartis Foundation Symposium 280

Sepsis: New Insights, New Therapies: Novartis Foundation Symposium 280

Editor(s): Derek J. Chadwick, Jamie Goode

Published Online: 7 OCT 2008

Print ISBN: 9780470027981

Online ISBN: 9780470059593

DOI: 10.1002/9780470059593

Series Editor(s): Novartis Foundation

About this Book

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.

  • Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it
  • Describes numerous pharmacological approaches to therapy for early and late sepsis
  • Includes detailed discussion of the various physiological systems implicated in sepsis
  • Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis

Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.

Table of contents

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    2. Chapter 4

      Blockade of Apoptosis as a Rational Therapeutic Strategy for the Treatment of Sepsis (pages 37–52)

      Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl, Joanne L. Lomas-Neira, Ryan Swan and Chun-Shiang Chung

    3. Chapter 5

      Modulating Neutrophil Apoptosis (pages 53–72)

      John C. Marshall, Zeenat Malam and Songhui Jia

    4. Chapter 6

      HMGB1 as a Potential Therapeutic Target (pages 73–91)

      Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and Andrew E. Sama

    5. Chapter 8

      Choosing the Right Substrate (pages 108–127)

      Xavier Leverve, Cécile Batandier and Eric Fontaine

    6. Chapter 9

      Inhibiting Glycogen Synthase Kinase 3β in Sepsis (pages 128–146)

      Laura Dugo, Marika Collin, David A. Allen, Nimesh S. A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob and Christoph Thiemermann

    7. Chapter 16

      Beta-Blockade in Burns (pages 238–251)

      C. T. Pereira, M. G. Jeschke and D. N. Herndon

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