Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium 281

Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium 281

Editor(s): Gregory Bock, Jamie Goode

Published Online: 16 MAR 2007

Print ISBN: 9780470027554

Online ISBN: 9780470062128

DOI: 10.1002/9780470062128

Series Editor(s): Novartis Foundation

About this Book

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following:

  • What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
  • Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
  • Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?

Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Table of contents

    1. You have free access to this content
    2. Molecular Pathways for Lymphangiogenesis and their Role in Human Disease (pages 38–49)

      Steven A. Stacker, Rae H. Farnsworth, Tara Karnezis, Ramin Shayan, Darrin P. Smith, Karri Paavonen, Natalia Davydova, Carol Caesar, Rachael Inder, Megan E. Baldwin, Bradley K. McColl, Sally Roufail, Richard A. Williams, Richard A. Hughes, Kari Alitalo and Marc G. Achen

    3. Genetic Resistance to Smallpox: Lessons from Mousepox (pages 129–140)

      Gunasegaran Karupiah, Vijay Panchanathan, Isaac G. Sakala and Geeta Chaudhri

    4. You have free access to this content
    5. You have free access to this content