Drug Transporters: Molecular Characterization and Role in Drug Disposition

Drug Transporters: Molecular Characterization and Role in Drug Disposition

Editor(s): Guofeng You, Marilyn E. Morris

Published Online: 20 NOV 2006

Print ISBN: 9780471784913

Online ISBN: 9780470140505

DOI: 10.1002/9780470140505

About this Book

A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body

The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition:
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Provides a comprehensive overview of drug transporters
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Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy
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Describes transporter-mediated drug disposition, a newly emerging field in drug therapy
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Gives a comprehensive summary of drug transport across biological membranes
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in the liver, brain, kidney, and intestine
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Provides balanced coverage of mechanistic aspects and functional outcomes
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Features chapters contributed by distinguished scientists in their specialty areas
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Provides sufficient detail to enable non-specialists to understand the principles and techniques

This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields.

Table of contents

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    2. You have free access to this content
    3. Chapter 3

      Organic Cation/Carnitine Transporters (pages 35–50)

      Ijaz A. Qureshi, Ihsan Elimrani, Ernest Seidman and Grant Mitchell

    4. Chapter 4

      Organic Anion Transporters (pages 51–73)

      Megha Nagle, David M. Truong, Vibha Bhatnagar, Gregory Kaler, Kevin T. Bush, Wei Wu, Satish A. Eraly and Sanjay K. Nigam

    5. Chapter 6

      Mammalian Oligopeptide Transporters (pages 105–145)

      Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson and Gregory T. Knipp

    6. Chapter 9

      Bile Acid Transporters (pages 201–221)

      Jyrki J. Eloranta and Gerd A. Kullak-Ublick

    7. Chapter 12

      Breast Cancer Resistance Protein (pages 319–358)

      Robert W. Robey, Orsolya Polgar, John Deeken, Kenneth K. W. To and Susan E. Bates

    8. Chapter 13

      Drug Transport in the Liver (pages 359–410)

      Pieter Annaert, Brandon Swift, Jin Kyung Lee and Kim L. R. Brouwer

    9. Chapter 14

      Drug Transport in the Brain (pages 411–461)

      Patrick T. Ronaldson, Karlo Babakhanian and Reina Bendayan

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