Combating the Threat of Pandemic Influenza: Drug Discovery Approaches

Combating the Threat of Pandemic Influenza: Drug Discovery Approaches

Editor(s): Paul F. Torrence

Published Online: 14 MAR 2007

Print ISBN: 9780470118795

Online ISBN: 9780470179727

DOI: 10.1002/9780470179727

About this Book

Drug discovery for influenza antivirals

Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health-related endeavor.

With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering:
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Existing antivirals, including broadly effective anti-respiratory virus agents
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The development of high-throughput screening assays
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IFN resistance
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The development of nucleic acid-based antiviral drugs
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Antiviral RNAi strategies targeting influenza virus
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Other promising antiviral drug discovery strategies

Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Table of contents

    1. You have free access to this content
    2. You have free access to this content
    3. Chapter 5

      Current Status on Development of Nucleic Acid-Based Antiviral Drugs Against Influenza Virus Infection (pages 126–147)

      Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.-Q. Sun, Roderic M. K. Dale and Andres M. Salazar

    4. Chapter 7

      Promising Antiviral Glyco-Molecules from an Edible Alga (pages 166–182)

      Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Yuko Ohta, Jung-Bum Lee, Minoru Hashimoto and Takahisa Nakano

    5. Chapter 11

      Novel Influenza Therapeutics (pages 247–264)

      Laura M. Aschenbrenner, Nicole Pelletier, Mang Yu and Fang Fang

    6. You have free access to this content

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