Drug Metabolism in Drug Design and Development: Basic Concepts and Practice

Drug Metabolism in Drug Design and Development: Basic Concepts and Practice

Editor(s): Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys

Published Online: 30 APR 2007

Print ISBN: 9780471733133

Online ISBN: 9780470191699

DOI: 10.1002/9780470191699

About this Book

The essentials of drug metabolism vital to developing new therapeutic entities

Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers:

Basic concepts of drug metabolism

The role of drug metabolism in the pharmaceutical industry

Analytical techniques in drug metabolism

Common experimental approaches and protocols

Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques.

This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Table of contents

    1. You have free access to this content
    2. Chapter 12

      Introduction to NMR and Its Application in Metabolite Structure Determination (pages 369–409)

      Xiaohua Huang, Robert Powers, Adrienne Tymiak, Robert Espina and Vikram Roongta

    3. Chapter 15

      Reaction Phenotyping (pages 477–512)

      Susan Hurst, J. Andrew Williams and Steven Hansel

    4. You have free access to this content