Molecular and Biochemical Toxicology, Fourth Edition

Molecular and Biochemical Toxicology, Fourth Edition

Editor(s): Robert C. Smart, Ernest Hodgson

Published Online: 23 OCT 2007

Print ISBN: 9780470102114

Online ISBN: 9780470285251

DOI: 10.1002/9780470285251

About this Book

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

  • New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
  • Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
  • Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Table of contents

    1. You have free access to this content
    2. You have free access to this content
    3. Chapter 6

      Bioinformatics (pages 81–107)

      Eric A. Stone and Dahlia M. Nielsen

    4. Chapter 10

      Phase 1 Metabolism of Toxicants and Metabolic Interactions (pages 173–203)

      Ernest Hodgson, Parikshit C. Das, Taehyeon M. Cho and Randy L. Rose

    5. Chapter 24

      Carcinogenesis (pages 537–586)

      Robert C. Smart, Sarah J. Ewing and Kari D. Loomis

    6. Chapter 28

      Hepatotoxicity (pages 671–692)

      Andrew D. Wallace and Sharon A. Meyer

    7. Chapter 32

      Immunotoxicity (pages 765–803)

      Maryjane K. Selgrade, Dori R. Germolec, Robert W. Luebke, Ralph J. Smialowicz, Marsha D. Ward and Christal C. Bowman

    8. You have free access to this content