Nuclear Receptors in Drug Metabolism

Copyright © 2009 John Wiley & Sons, Inc.

Nuclear Receptors in Drug Metabolism

Editor(s): Wen Xie

Published Online: 14 MAY 2008

Print ISBN: 9780470086797

Online ISBN: 9780470409107

DOI: 10.1002/9780470409107

About this Book

Product Information

About The Product

This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xxii)

    2. You have free access to this content
      Color Plates (pages c1–c8)

    3. Chapter 1

      Drug Metabolism: Significance and Challenges (pages 1–41)

      Chandra Prakash and Alfin D. N. Vaz

    4. Chapter 2

      Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors (pages 43–59)

      Tao Li, Junichiro Sonoda and Ronald M. Evans

    5. Chapter 3

      Nuclear Receptor-Mediated Regulation of Phase II Conjugating Enzymes (pages 61–110)

      Oliver Barbier

    6. Chapter 4

      Nuclear Receptor-Mediated Regulation of Drug Transporters (pages 111–146)

      Oliver Burk

    7. Chapter 5

      Structure and Function of PXR and CAR (pages 147–166)

      X. Edward Zhou and H. Eric Xu

    8. Chapter 6

      Xenobiotic Receptor Cofactors and Coregulators (pages 167–183)

      John Y. L. Chiang

    9. Chapter 7

      Animal Models of Xenobiotic Nuclear Receptors and their Utility in Drug Development (pages 185–210)

      Haibiao Gong and Wen Xie

    10. Chapter 8

      Nuclear Receptors and Drug–Drug Interactions with Prescription and Herbal Medicines (pages 211–239)

      Rommel G. Tirona and Richard B. Kim

    11. Chapter 9

      Genetic Variants of Xenobiotic Receptors and their Implications in Drug Metabolism and Pharmacogenetics (pages 241–273)

      Jatinder Lamba and Erin G. Schuetz

    12. Chapter 10

      Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by other Nuclear Receptors (pages 275–300)

      Martin Wagner, Gernot Zollner and Michael Trauner

    13. Chapter 11

      Emerging Role of Retinoid-Related Orphan Receptor (ROR) and its Cross Talk with LXR (Liver X Receptor) in the Regulation of Drug-Metabolizing Enzymes (pages 301–318)

      Taira Wada and Wen Xie

    14. You have free access to this content
      Index (pages 319–330)

SEARCH