Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

Copyright © 2009 John Wiley & Sons, Inc.

Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

Editor(s): Valentin K. Gribkoff, Leonard K. Kaczmarek

Published Online: 11 JUL 2008

Print ISBN: 9780471930136

Online ISBN: 9780470429907

DOI: 10.1002/9780470429907

About this Book

Product Information

About The Product

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

Table of contents

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      Frontmatter (pages i–xiv)

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      Color Plates (pages c1–c12)

  3. Part I: Neuronal Voltage-Gated Ion Channel Functions

    1. Chapter 1

      Neuronal L-Type Voltage-Gated Calcium Channels (pages 1–34)

      Alexander Scriabine and David J. Triggle

    2. Chapter 2

      Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders (pages 35–66)

      Elizabeth Tringham and Terrance P. Snutch

    3. Chapter 3

      Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (pages 67–104)

      Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black and Stephen G. Waxman

    4. Chapter 4

      The Role of Ion Channels in the Etiology and Development of Gliomas (pages 105–126)

      Amy K. Weaver and Harald Sontheimer

    5. Chapter 5

      Shaker Family Kv1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons (pages 127–154)

      Helene Vacher and James S. Trimmer

    6. Chapter 6

      Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (pages 155–191)

      Elizabeth A. Jonas

    7. Chapter 7

      Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (pages 193–215)

      Valentin K. Gribkoff and Leonard K. Kaczmarek

  4. Part II: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function

    1. Chapter 8

      Alternative Splicing of Neuronal Cav2 Calcium Channels (pages 217–250)

      Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis and Jesica Raingo

    2. Chapter 9

      Effect of Hypoxia/Ischemia on Voltage-Dependent Channels (pages 251–277)

      Xiang Q. Gu, Hang Yao and Gabriel G. Haddad

    3. Chapter 10

      In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (pages 279–289)

      Smitha Reddy, Mohammad Shahidullah and Irwin B. Levitan

    4. Chapter 11

      Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons (pages 291–316)

      Mark S. Shapiro and Nikita Gamper

    5. Chapter 12

      BK Channels: Regulation of Expression and Physiological Impact (pages 317–342)

      Pallob Kundu, Abderrahmane Alioua, Yogesh Kumar, Rong Lu, Jimmy W. Ou, Enrique Sanchez-Pastor, Min Li, Enrico Stefani and Ligia Toro

    6. Chapter 13

      Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (pages 343–361)

      KeWei Wang and Jijie Chai

  5. Part III: Drug Discovery Targets and Technology

    1. Chapter 14

      Sodium Channel Blockers for the Treatment of Chronic Pain (pages 363–391)

      Mark R. Bowlby and Edward Kaftan

    2. Chapter 15

      Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (pages 393–421)

      Steven I. Dworetzky and Valentin K. Gribkoff

    3. Chapter 16

      Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels (pages 423–441)

      John E. Starrett

    4. Chapter 17

      High-Throughput Screening Technologies in Ion Channel Drug Discovery (pages 443–466)

      Edward B. Stevens, Andrew D. Whyment and J. Mark Treherne

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      Index (pages 467–475)

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