Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173

Copyright © 2009 John Wiley & Sons, Inc.

Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173

Editor(s): Imma Ferrer, E. Michael Thurman

Published Online: 11 JUL 2008

Print ISBN: 9780470137970

Online ISBN: 9780470429969

DOI: 10.1002/9780470429969

Series Editor(s): J. D. Winefordner

About this Book

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About The Product

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants-such as antibiotics, steroids, analgesics-using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xii)

  2. Part I: Principles and Theoretical Aspects of Accurate Mass

    1. Chapter 1

      Accurate Mass Measurements With Orthogonal Axis Time-of-Flight Mass Spectrometry (pages 1–15)

      John C. Fjeldsted

    2. Chapter 2

      The Mass Defect, Isotope Clusters, and Accurate Mass for Elemental Determination (pages 17–31)

      E. Michael Thurman and Imma Ferrer

  3. Part II: Tools for Unknown Identification Using Accurate Mass

    1. Chapter 3

      Ion Compositions Determined with Increasing Simplicity (pages 33–56)

      Andrew H. Grange and G. Wayne Sovocool

    2. Chapter 4

      Existence and Use of Accurate Mass Databases and Elemental Composition Tools for Target and Non-Target Analyses (pages 57–70)

      Imma Ferrer and E. Michael Thurman

    3. Chapter 5

      Use of UPLC-(Q)TOF MS for Rapid Screening of Organic Micropollutants in Water (pages 71–87)

      Félix Hernández, Juan V. Sancho and María Ibáñez

    4. Chapter 6

      The Use of Accurate Mass, Isotope Ratios, and MS/MS for the Analysis of PPCPs in Water (pages 89–102)

      Michael C. Zumwalt

  4. Part III: Applications of LC/TOF-MS for the Identification of Small Molecules

    1. Chapter 7

      Applications of LC/TOF-MS in the Environmental Field: When Did It Start and Where Is It Going? (pages 103–111)

      Imma Ferrer and E. Michael Thurman

    2. Chapter 8

      Liquid Chromatography and Ambient Ionization Time-of-Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals (pages 113–132)

      Facundo M. Fernández, Christina Y. Hampton, Leonard Nyadong, Arti Navare and Mark Kwasnik

    3. Chapter 9

      Quantitative Analysis of Veterinary Drug Residues by Sub 2-µm Particulate High-Performance Liquid Chromatography Columns and Time-of-Flight Mass Spectrometry (UPLC-TOF) (pages 133–149)

      Anton Kaufmann

    4. Chapter 10

      Industrial Applications of Liquid Chromatography Time-of-Flight Mass Spectrometry (pages 151–172)

      Jeffrey R. Gilbert, Jesse L. Balcer, Scott A. Young, Dan A. Markham, Dennis O. Duebelbeis and Paul Lewer

    5. Chapter 11

      Comprehensive Toxicological and Forensic Drug Screening by LC/TOF-MS (pages 173–195)

      Ilkka Ojanperä, Anna Pelander and Suvi Ojanperä

    6. Chapter 12

      Application of UPLC/TOF-MS for Residue Analysis of Veterinary Drugs and Growth-Promoting Agents in Products of Animal Origin (pages 197–228)

      Alida(Linda)A.M. Stolker

    7. Chapter 13

      Accurate Mass Measurements With a Reflectron Time-of-Flight Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for the Identification of Unknown Compounds below Masses of 500 DA (pages 229–245)

      O. David Sparkman, Patrick R. Jones and Matthew Curtis

    8. Chapter 14

      Comparison Of LC/TOF-MS and LC/MS-MS for the Analysis of 100 Pesticides in Food: Finding the “Crossover Point” (pages 247–257)

      E. Michael Thurman, Imma Ferrer, Jerry A. Zweigenbaum and Paul A. Zavitsanos

    1. You have free access to this content
      Index (pages 259–261)

    1. You have free access to this content
      Chemical Analysis (pages 262–267)

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