Emerging Technology Platforms for Stem Cells

Copyright © 2009 John Wiley & Sons, Inc.

Emerging Technology Platforms for Stem Cells

Editor(s): Uma Lakshmipathy, Jonathan D. Chesnut, Bhaskar Thyagarajan

Published Online: 17 APR 2009

Print ISBN: 9780470146934

Online ISBN: 9780470454923

DOI: 10.1002/9780470454923

About this Book

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About The Product

This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high-throughput screening, and stem cell genetic modification with their use for drug delivery.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xvii)

    1. You have free access to this content
      Color Plates (pages c1–c24)

  3. I

    1. Chapter 1

      Derivation Methods for Human Embryonic Stem Cells: Past, Present, and Future (pages 1–18)

      Necati Findikli and Mohan C. Vemuri

    2. Chapter 2

      Isolation of Human Embryonic Stem Cells from Various Stages of the Human Embryo (pages 19–27)

      Yury Verlinsky, Nick Strelchenko, Valery Kukharenko, Artem Shkumatov, Svetlana Rechitsky, Oleg Verlinsky and Anver Kuliev

    3. Chapter 3

      Derivation of Stem Cells from Epiblasts (pages 29–37)

      Michal Amit

    4. Chapter 4

      Derivation of Embryonic Stem Cells from Parthenogenetic Eggs (pages 39–49)

      Jose Cibelli

    5. Chapter 5

      Reprogramming Developmental Potential (pages 51–85)

      Costas A. Lyssiotis, Bradley D. Charette and Luke L. Lairson

  4. II

    1. Chapter 6

      Adult Stem Cells and Their Role in Endogenous Tissue Repair (pages 87–109)

      Nadia Sachewsky and Cindi M. Morshead

    2. Chapter 7

      Greater Differentiation Potential of Adult Stem Cells (pages 111–128)

      Carlos Clavel and Catherine Verfaillie

    3. Chapter 8

      Cancer Stem Cells (pages 129–151)

      Scott J. Dylla, In-Kyung Park and Austin L. Gurney

    4. Chapter 9

      Large-Scale Production of Adult Stem Cells for Clinical Use (pages 153–168)

      Kristin L. Goltry, Brian S. Hampson, Naia A. Venturi and Ronnda L. Bartel

  5. III

    1. Chapter 10

      Genetic and Epigenetic Features of Stem Cells (pages 169–202)

      Richard Josephson and Jonathan Auerbach

    2. Chapter 11

      Directed Differentiation of Embryonic Stem Cells (pages 203–233)

      Marjorie Pick

    3. Chapter 12

      Identification of Signaling Pathways Involved During Differentiation (pages 235–247)

      Takumi Miura

  6. IV

    1. Chapter 13

      Media and Extra Cellular Matrix Requirements for Large-Scale ESC Growth (pages 249–274)

      Allan J. Robins and Thomas C. Schulz

    2. Chapter 14

      Automated Method for Embryonic Stem Cell Culture (pages 275–281)

      Stefanie Terstegge and Oliver Brüstle

    3. Chapter 15

      Quantitative 2D Imaging of Human Embryonic Stem Cells (pages 283–290)

      Steve K. W. Oh, Allen K. Chen, Andre B. H. Choo and Ivan Reading

    4. Chapter 16

      Nanobiotechnology for Stem Cell Culture and Maintenance (pages 291–310)

      Minseok S. Kim, Wonhye Lee and Je-Kyun Park

    5. Chapter 17

      Engineering Microenvironments to Control Stem Cell Functions (pages 311–326)

      Danielle An-Chi Tsou and Song Li

  7. V

    1. Chapter 18

      Improved Lentiviral Gene Delivery Tools for Stem Cells (pages 327–340)

      Sanjay Vasu, Jian-Ping Yang and Wieslaw Kudlicki

    2. Chapter 19

      Sleeping Beauty-Mediated Transposition in Stem Cells (pages 341–362)

      Andrew Wilber, Jakub Tolar, Bruce R. Blazar, Catherine M. Verfaillie, Uma Lakshmipathy, Dan S. Kaufman and R. Scott McIvor

    3. Chapter 20

      PhiC31 Integrase for Modification of Stem Cells (pages 363–378)

      Wonil Edward Jung and Michele P. Calos

    4. Chapter 21

      Cell Engineering Using Integrase and Recombinase Systems (pages 379–384)

      Takefumi Sone, Fumiko Nishiumi, Kazuhide Yahata, Yukari Sasaki, Hiroe Kishine, Taichi Andoh, Ken Inoue, Fumio Imamoto, Bhaskar Thyagarajan and Jonathan D. Chesnut

  8. VI

    1. Chapter 22

      Human Embryonic Stem Cell-Derived Cardiomyocytes for Cell Therapy and Drug Discovery (pages 395–415)

      William Sun and Robert Zweigerdt

    2. Chapter 23

      Human Embryonic Stem Cells in Drug Discovery (pages 417–437)

      Catharina Ellerström, Petter Björquist, Peter Sartipy, Johan Hyllner and Raimund Strehl

    3. Chapter 24

      Characterization and Culturing of Adipose-Derived Precursor Cells (pages 439–462)

      Dietmar W. Hutmacher, Johannes Reichert, Joanna Olkowska-Truchanowicz, David Leong and Thiam Chye Lim

    4. Chapter 25

      Bringing Mesenchymal Stem Cells into the Clinic (pages 463–481)

      Robert Deans

    1. You have free access to this content
      Index (pages 483–505)

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