Polyphosphazenes for Biomedical Applications

Polyphosphazenes for Biomedical Applications

Editor(s): Alexander K. Andrianov

Published Online: 10 NOV 2008

Print ISBN: 9780470193433

Online ISBN: 9780470478882

DOI: 10.1002/9780470478882

About this Book

Brings together, analyzes, and contextualizes the latest findings and practical applications

Polyphosphazenes, an emerging class of polymers, include macromolecules, which have been proven to be biocompatible, biodegradable, and bioactive. Their unprecedented structural diversity and unique properties make them suitable as vaccine adjuvants, microencapsulating agents, biodegradable materials, scaffolds for tissue engineering, biocompatible coatings, and carriers for gene delivery.

Polyphosphazenes for Biomedical Applications offers a thorough review of polyphosphazene research findings in the life sciences, chemistry, and chemical engineering. It emphasizes biomedical applications as well as recent advances in polyphosphazene development such as high-throughput discovery and the latest controlled methods of synthesis. The book brings together, analyzes, and contextualizes a wealth of knowledge that previously could only be found scattered throughout the scientific literature.

Following two introductory chapters, the book reviews:

  • Vaccine delivery and immunomodulation

  • Biomaterials

  • Drug delivery systems

  • Biodetection

  • Well-defined polyphosphazenes: synthetic aspects and novel molecular architectures

All the chapters have been written by leading researchers in the field. Editor Alexander Andrianov, who has led the effort to commercialize polyphosphazenes for biomedical applications, has carefully reviewed and edited all chapters to ensure readability, accuracy, and thoroughness.

Polyphosphazenes for Biomedical Applications is not only intended for researchers working in polyphosphazene chemistry, but also for all researchers seeking solutions to problems arising in the areas of biomaterials, drug delivery systems, and controlled release formulations.

Table of contents

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  1. Part I: Introduction

  2. Part II: Vaccine Delivery and Immunomodulation

    1. Chapter 7

      Polyphosphazene Immunoadjuvants for Intradermal Vaccine Delivery (pages 101–116)

      Alexander K. Andrianov, Daniel P. DeCollibus, Helice A. Gillis, Henry H. Kha and Alexander Marin

  3. Part III: Biomaterials

    1. Chapter 8

      Biodegradable Polyphosphazene Scaffolds for Tissue Engineering (pages 117–138)

      Syam P. Nukavarapu, Sangamesh G. Kumbar, Harry R. Allcock and Cato T. Laurencin

    2. Chapter 9

      Biodegradable Polyphosphazene Blends for Biomedical Applications (pages 139–154)

      Meng Deng, Lakshmi S. Nair, Nicholas R. Krogman, Harry R. Allcock and Cato T. Laurencin

    3. Chapter 11

      Electrospun Polyphosphazene Nanofibers for In Vitro Osteoblast Culture (pages 169–184)

      Maria Teresa Conconi, Paolo Carampin, Silvano Lora, Claudio Grandi and Pier Paolo Parnigotto

    4. Chapter 12

      Phosphazenes and Surfaces (pages 185–224)

      Mario Gleria, Roberto Milani, Roberta Bertani, Angelo Boscolo Boscoletto and Roger De Jaeger

  4. Part IV: Drug Delivery Systems

  5. Part V: Biodetection

  6. Part VI: Well-Defined Polyphosphazenes: Synthetic Aspects and Novel Molecular Architectures

    1. You have free access to this content
    1. You have free access to this content