ABC Transporters and Multidrug Resistance

ABC Transporters and Multidrug Resistance

Editor(s): Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

Published Online: 15 JUN 2009

Print ISBN: 9780470227343

Online ISBN: 9780470495131

DOI: 10.1002/9780470495131

Series Editor(s): Binghe Wang

About this Book

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.

ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Table of contents

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  1. Part I: ABC Proteins: An Overview and Description of the Structure, Genome, Normal Tissue Expression, Physiological Aspect, and Mechanism of Action

    1. Chapter 1

      The P-Glycoprotein 170: Just a Multidrug Resistance Protein or a Protean Molecule? (pages 15–46)

      Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier and Marie-Hélène Ratinaud

    2. Chapter 3

      ABCG2: A New Challenge in Cancer Drug Resistance (pages 83–117)

      Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch and Susan E. Bates

  2. Part II: ABC Proteins and Oncology: Expression, Detection, and Implication of ABC Proteins in Hematological Malignancies and Solid Tumors

  3. Part III: ABC Proteins and Pathogenic Microorganisms

  4. Part IV: Multidrug Resistance (MDR) Modulation through Inhibition of ABC Transporters: Design of Inhibitors and Mechanism of Action

  5. Part V: Biological and Clinical Aspects of Multidrug Resistance: The Role of the Transporters at the Main Protection Barriers (ABCB1, ABCC1, ABCC2, ABCG2) on the Bioavailability of Many Types of Drugs and Medications

    1. You have free access to this content
    1. You have free access to this content