Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications

Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications

Editor(s): Claudiu T. Supuran, Jean-Yves Winum

Published Online: 4 NOV 2009

Print ISBN: 9780470275009

Online ISBN: 9780470508169

DOI: 10.1002/9780470508169

Series Editor(s): Binghe Wang

About this Book

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes

The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.

With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as:

  • Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G

  • Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions

  • Cross reactivity of zinc-enzyme inhibitors and activators

  • The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins

  • Clinical applications

An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part I: Introduction

  2. Part II: Drug Design of Carbonic Anhydrase Inhibitors and Activators

    1. Chapter 4

      X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (pages 138–66)

      Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. Supuran and Giuseppina De Simone

    2. Chapter 11

      Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition (pages 255–272)

      Jean-Michel Dogné, Anne Thiry, Bernard Masereel and Claudiu T. Supuran

  3. Part III: Drug Design of Matrix Metalloproteinase Inhibitors

  4. Part IV: Drug Design of Bacterial Zinc Protease Inhibitors

  5. Part V: Drug Design Studies of Other Zinc-Containing Enzymes

    1. Chapter 32

      Angiotensin Converting Enzyme (ACE) Inhibitors (pages 749–787)

      Ana Cámara-Artigas, Vicente Jara-Pérez and Montserrat Andújar-Sánchez

    2. Chapter 37

      Targeting HIV-1 Integrase Zinc Binding Motif (pages 911–936)

      Mario Sechi, Mauro Carcelli, Dominga Rogolino and Nouri Neamati

    3. Chapter 39

      Dihydroorotase Inhibitors (pages 951–979)

      Mihwa Lee, Megan J. Maher, Richard I. Christopherson and J. Mitchell Guss

    1. You have free access to this content

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