Ciba Foundation Symposium 124 - Functions of the Proteoglycans

Ciba Foundation Symposium 124 - Functions of the Proteoglycans

Editor(s): David Evered, Julie Whelan

Published Online: 28 SEP 2007

Print ISBN: 9780471910909

Online ISBN: 9780470513385

DOI: 10.1002/9780470513385

About this Book

Presents a comprehensive review of current proteoglycan research, which is providing fresh insights into many major chronic diseases. The proteoglycans are a family of macromolecules which contain one or more glycosaminoglycan chains covalently bound to a core protein. Proteoglycans are a major component of the extracellular matrix of connective tissues and help to determine its volume, resiliency, and organization. They are an important medium through which nutrients, hormones, and other solutes are transported to cells, and they play a significant role in cell-cell interactions. Disturbances in proteoglycans occur in rheumatic and connective tissue disorders, degenerative bone disease, vascular disease, renal disease, and malignant disorders.

Table of contents

    1. You have free access to this content
    2. Cartilage Proteoglycans (pages 30–46)

      Timothy E. Hardingham, Matthew Beardmore-Gray, David G. Dunham and Anthony Ratcliffe

    3. Functions of Proteoglycans at the Cell Surface (pages 143–157)

      Magnus Höök, Anne Woods, Staffan Johansson, Lena Kjellén and John R. Couchman

    4. Structure and Function of Basement Membrane Proteoglycans (pages 189–203)

      Mats Paulsson, Sakuhei Fujiwara, Marie Dziadek, Rupert Timpl, Gunnar Pejler, Gudrun Bäckström, Ulf Lindahl and Jürgen Engel

    5. You have free access to this content
    6. You have free access to this content

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