Ciba Foundation Symposium 125 - Junctional Complexes of Epithelial Cells

Ciba Foundation Symposium 125 - Junctional Complexes of Epithelial Cells

Editor(s): Gregory Bock, Sarah Clark

Published Online: 28 SEP 2007

Print ISBN: 9780471910916

Online ISBN: 9780470513408

DOI: 10.1002/9780470513408

About this Book

Epithelial cells cover the outer and inner surfaces of the body, forming a selective polarized barrier between the intercellualar space and the 'external' world. Linking the cells of this continuous layer and contributing to epithelial organization and function are specialized membrane domains--desmosomes, gap junctions, and occluding junctions. The contributors to this multidisciplinary symposium volume explore the nature of such junctional structures, focusing on the molecular organization and diversity of their constituent proteins, their formation and control, and interactions with ions and cytoskeletal elements. The physiological significance of cell-cell interaction in epithelia is considered, with reference to cell adhesion, barrier formation and intercellular communication, and to the functional implications for tissue architecture, embryonic development, morphogenesis and carcinogenesis.

Table of contents

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    2. On the Molecular Organization, Diversity and Functions of Desmosomal Proteins (pages 3–25)

      Malcolm S. Steinberg, Hisato Shida, George J. Giudice, Mariko Shida, Nipam H. Patel and Orest W. Blaschuk

    3. The Desmosomal Plaque and the Cytoskeleton (pages 26–48)

      Werner W. Franke, Pamela Cowin, Monika Schmelz and Hans-Peter Kapprell

    4. Molecular Structure of the Gap Junctional Channel (pages 92–107)

      M. E. Finbow, T. E. J. Buultjens, S. John, E. Kam, L. Meagher and J. D. Pitts

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    6. You have free access to this content

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