Ciba Foundation Symposium 129 - Autoimmunity and Autoimmune Disease

Copyright © Ciba Foundation 1987

Ciba Foundation Symposium 129 - Autoimmunity and Autoimmune Disease

Editor(s): David Evered, Julie Whelm

Published Online: 28 SEP 2007

Print ISBN: 9780471910954

Online ISBN: 9780470513484

DOI: 10.1002/9780470513484

About this Book

Product Information

About The Product

This work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface-derived ``self'' antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and treatment; possible links between autoimmunity and genetic complement deficiency; the contributions of interferons and class II HLA antigen expression to autoimmunity; and the potential of monoclonal antibodies and other biotechnological advances in treating human autoimmune conditions.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction (pages 1–2)

      D. K. Peters

    3. Cardiac Myosin and Autoimmune Myocarditis (pages 3–24)

      Noel R. Rose, Kirk W. Beisel, Ahvie Herskowitz, Nikolaus Neu, Luanne J. Wolfgram, Floria L. Alvarez, Monica D. Traystman and Susan W. Craig

    4. Intracellular Autoantigens: Diagnostic Fingerprints but Aetiological Dilemmas (pages 25–42)

      Eng M. Tan, Georg Reimer and Kevin Sullivan

    5. Significance of Carbohydrate Components of Cell Surfaces (pages 43–58)

      Ten Feizi

    6. How is Tolerance Generated? (pages 59–72)

      Sir G. J. V. Nossal

    7. Therapeutic Immune Regulation in Experimental Interstitial Nephritis with Suppressor T Cells and their Soluble Factors (pages 73–87)

      Carolyn J. Kelly, Michael D. Clayman, William H. Hines and Eric G. Neilson

    8. Regulation of HLA Class II Expression and its Role in Autoimmune Disease (pages 88–108)

      Marc Feldmann

    9. Idiotypes and Autoimmunity (pages 109–122)

      John F. Kearney, Meenal Vakil and Donard S. Dwyer

    10. Molecular Basis for the Cross-Reactive Idiotypes on Human Anti-Igg Autoantibodies (Rheumatoid Factors) (pages 123–134)

      Dennis A. Carson, Pojen P. Chen, Thomas J. Kipps, Victor Radoux, Frank Jirik, Robert D. Goldfien, Robert I. Fox, Gregg J. Silverman and Sherman Fong

    11. Autoimmunity and Immunodeficiency Disease (pages 135–148)

      Fred S. Rosen

    12. Deficiency of the Effector Mechanisms of the Immune Response and Autoimmunity (pages 149–183)

      P. J. Lachmann and M. J. Walport

    13. Monoclonal Anti-La Antibody Therapy in Animal Models of Autoimmune Disease (pages 184–193)

      H. O. McDevitt, R. Perry and L. A. Steinman

    14. Monoclonal Antibodies for the Depletion of Specific Subpopulations of Lymphocytes (pages 194–208)

      Herman Waldmann, Steve Cobbold, Shixin Qin, Richard Benjamin, Tony Nash, Jane Welsh and Georgia Tarnesby

    15. Manipulation of Idiotype Networks in Autoimmunity (pages 209–222)

      Ivan M. Roitt and Anne Cooke

    16. Interferons: Cytokines in Autoimmunity (pages 223–233)

      Michel Revel and Amichai Schattner

    17. Specific Immunoabsorption (pages 234–265)

      C. M. Lockwood, C. O. S. Savage and C. D. Pusey

    18. Chairman's Summing-Up (pages 266–267)

      D.K. Peters

    19. You have free access to this content
      Index of Contributers (pages 268–269)

    20. You have free access to this content
      Subject Index (pages 270–278)

SEARCH