Ciba Foundation Symposium 130 - Molecular Approaches to Human Polygenic Disease

Ciba Foundation Symposium 130 - Molecular Approaches to Human Polygenic Disease

Editor(s): Gregory Bock, Geralyn M. Collins

Published Online: 28 SEP 2007

Print ISBN: 9780471910961

Online ISBN: 9780470513507

DOI: 10.1002/9780470513507

About this Book

Many common human diseases have a multifactorial origin: they are influenced by a person's genetic predisposition as well as by factors in the environment. This volume deals with the application of recombinant DNA techniques to the identification of diseases that have more than one inherited component. Focus is on the polygenic factors responsible for coronary atherosclerosis. Several other disorders having a polygenic origin are also discussed, including hypertension, diabetes mellitus, psychiatric diseases, and autoimmune (HLA-related) disorders. Problems raised by the study of different families or different populations are covered, as well as the possibility of applying molecular techniques to disease prevention--for example, through gene therapy. Also, some of the ethical issues that relate to human gene mapping are briefly explored.

Table of contents

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    2. Gene Therapy: Efforts at Developing Large Animal Models for Autologous Bone Marrow Transplant and Gene Transfer with Retroviral Vectors (pages 229–246)

      Martin A. Eglitis, Philip W. Kantoff, Jeanne R. McLachlin, Al Gillio, Alan W. Flake, Claudio Bordignon, Robert C. Moen, Evelyn M. Karson, James A. Zwiebel, Donald B. Kohn, Eli Gilboa, R. Michael Blaese, Michael R. Harrison, Esmail D. Zanjani, Richard O'Reilly and W. French Anderson

    3. You have free access to this content
    4. You have free access to this content

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