Ciba Foundation Symposium 131 - Tumour Necrosis Factor and Related Cytotoxins

Ciba Foundation Symposium 131 - Tumour Necrosis Factor and Related Cytotoxins

Editor(s): Gregory Bock, Joan Marsh

Published Online: 28 SEP 2007

Print ISBN: 9780471910978

Online ISBN: 9780470513521

DOI: 10.1002/9780470513521

About this Book

The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts in vivo. The in vivo actions of TNF described here include haemorrhagic necrosis of tumors, cachexia, effects on the vasculature, and antiparasitic and antiviral activities. Also presented is some interesting data from the first stages of clinical trials of TNF as an anticancer agent.

Table of contents

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    2. Human Tumour Necrosis Factors: Structure and Receptor Interactions (pages 39–51)

      Bharat B. Aggarwal, Ramani A. Aiyer, Diane Pennica, Patrick W. Gray and David V. Goeddel

    3. Lymphotoxin: Cloning, Regulation and Mechanism of Killing (pages 64–87)

      Nancy H. Ruddle, Chang-Ben Li, Wei-Liang Tang, Patrick W. Gray and Katherine M. McGrath

    4. Structure – Functton Relationship of Tumour Necrosis Factor and its Mechanism of Action (pages 109–123)

      W. Fiers, P. Brouckaert, A. L. Goldberg, I. Kettelhut, P. Suffys, J. Tavernier, B. Vanhaesebroeck and F. Van Roy

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