Ciba Foundation Symposium 157 - Clinical Applications of TGF-β

Ciba Foundation Symposium 157 - Clinical Applications of TGF-β

Editor(s): Gregory R. Bock, Joan Marsh

Published Online: 28 SEP 2007

Print ISBN: 9780471928119

Online ISBN: 9780470514061

DOI: 10.1002/9780470514061

About this Book

TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.

Table of contents

    1. You have free access to this content
    2. Multiple Forms of TGF-β: Distinct Promoters and Differential Expression (pages 7–28)

      Anita B. Roberts, Seong-Jin Kim, Takafumi Noma, Adam B. Glick, Robert Lafyatis, Robert Lechleider, Sonia B. Jakowlew, Andrew Geiser, Michael A. O'Reilly, David Danielpour and Michael B. Sporn

    3. TGF-β: A Possible Autocrine Immune Regulator (pages 98–114)

      Catherine Lucas, Susan Wallick, Brian M Fendly, Irene Figari and Michael A. Palladino

    4. Effects of TGF-βs in the Liver: Cell Proliferation and Fibrogenesis (pages 165–177)

      Nelson Fausto, Janet E. Mead, Phillip A. Gruppuso, Alberto Castilla and Sonia B. Jakowlew

    5. Role of TGF-β1 in Experimental Glomerulonephritis (pages 178–193)

      Wayne A. Border, Seiya Okuda, Takamichi Nakamura, Lucia R. Languino and Erkki Ruoslahti

    6. In vivo and in vitro Effects of TGF-β1 on Normal and Neoplastic Haemopoiesis (pages 212–231)

      Francis W. Ruscetti, Claire Dubois, Lydia A. Falk, Sten E. Jacobsen, Garwin Sing, Dan L. Longo, Robert H. Wiltrout and Jonathan R. Keller

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