Ciba Foundation Symposium 157 - Clinical Applications of TGF-β

Copyright © Ciba Foundation 1991

Ciba Foundation Symposium 157 - Clinical Applications of TGF-β

Editor(s): Gregory R. Bock, Joan Marsh

Published Online: 28 SEP 2007

Print ISBN: 9780471928119

Online ISBN: 9780470514061

DOI: 10.1002/9780470514061

About this Book

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TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction: What is TGF-β? (pages 1–6)

      Michael B. Sporn and Anita B. Roberts

    3. Multiple Forms of TGF-β: Distinct Promoters and Differential Expression (pages 7–28)

      Anita B. Roberts, Seong-Jin Kim, Takafumi Noma, Adam B. Glick, Robert Lafyatis, Robert Lechleider, Sonia B. Jakowlew, Andrew Geiser, Michael A. O'Reilly, David Danielpour and Michael B. Sporn

    4. TGF-β Receptors (pages 29–50)

      Patricia R. Segarini

    5. Mechanisms in TGF-β Action (pages 51–65)

      Joan Massagué, Jyrki Heino and Marikki Laiho

    6. Regulation of Epithelial Proliferation by TGF-β (pages 66–80)

      Harold L. Moses, Edmund Y. Yang and Jennifer A. Pietenpol

    7. Latent forms of TGF-β: Molecular Structure and Mechanisms of Activation (pages 81–97)

      Kohei Miyazono and Carl-Henrik Heldin

    8. TGF-β: A Possible Autocrine Immune Regulator (pages 98–114)

      Catherine Lucas, Susan Wallick, Brian M Fendly, Irene Figari and Michael A. Palladino

    9. TGF-β and Wound Healing (pages 115–136)

      Edward P. Amento and L. Steven Beck

    10. The Effects of TGF-β on Bone (pages 137–151)

      Gregory R. Mundy

    11. TGF-β1 and Fibroblast Growth Factors Selectively Up-Regulate Tissue-Specific Fetal Genes in Cardiac Muscle Cells (pages 152–164)

      Thomas G. Parker, King-Lau Chow, Robert J. Schwartz and Michael D. Schneider

    12. Effects of TGF-βs in the Liver: Cell Proliferation and Fibrogenesis (pages 165–177)

      Nelson Fausto, Janet E. Mead, Phillip A. Gruppuso, Alberto Castilla and Sonia B. Jakowlew

    13. Role of TGF-β1 in Experimental Glomerulonephritis (pages 178–193)

      Wayne A. Border, Seiya Okuda, Takamichi Nakamura, Lucia R. Languino and Erkki Ruoslahti

    14. The Role of TGF-β in Pulmonary Fibrosis (pages 194–211)

      N. Khalil and A. H. Greenberg

    15. In vivo and in vitro Effects of TGF-β1 on Normal and Neoplastic Haemopoiesis (pages 212–231)

      Francis W. Ruscetti, Claire Dubois, Lydia A. Falk, Sten E. Jacobsen, Garwin Sing, Dan L. Longo, Robert H. Wiltrout and Jonathan R. Keller

    16. Expression of TGF-β2 in Human Glioblastoma: A Role in Resistance to Immune Rejection? (pages 232–241)

      Adriano Fontana, Stefan Bodmer, Karl Frei, Ursula Malipiero and Christine Siepl

    17. You have free access to this content
      Index of Contributors (pages 243–244)

    18. You have free access to this content
      Subject Index (pages 245–254)

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