Ciba Foundation Symposium 159 - Catalytic Antibodies

Copyright © Ciba Foundation 1991

Ciba Foundation Symposium 159 - Catalytic Antibodies

Editor(s): Derek J. Chadwick, Joan Marsh

Published Online: 28 SEP 2007

Print ISBN: 9780471929628

Online ISBN: 9780470514108

DOI: 10.1002/9780470514108

About this Book

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About The Product

Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic antibodies. The recognition that monoclonal antibodies can possess catalytic activity is a recent advance with profound ramifications for chemistry. In addition to their potential commercial applications as catalysts for reactions, for which there are no known enzymes, antibodies promise to provide valuable insight into the detailed mechanisms of biological catalysis and organic chemistry.

Table of contents

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      Front Matter (pages i–ix)

    2. Introduction (pages 1–3)

      W. P. Jencks

    3. A Catalytic Antibody Uses a Multistep Kinetic Sequence (pages 4–12)

      Stephen J. Benkovic, Joseph Adams, Kim D. Janda and Richard A. Lerner

    4. Structural Aspects of Antibodies and Antibody-Antigen Complexes (pages 13–39)

      Ian A. Wilson, Robyn L. Stanfield, James M. Rini, Jairo H. Arevalo, Ursula Schulze-Gahmen, Daved H. Fremont and Enrico A. Stura

    5. Nuclear Magnetic Resonance Studies of Antibody-Antigen Interactions (pages 40–54)

      Y. Arata

    6. Modelling Antibody Combining Sites: A Review (pages 55–71)

      Janet M. Thornton

    7. Approaches to the Design of Semisynthetic Metal-Dependent Catalytic Antibodies (pages 72–90)

      Grace R. Nakayama and Peter G. Schultz

    8. Construction of Combinatorial Antibody Expression Libraries in Escherichia Coli (pages 91–102)

      W. Huse

    9. Catalytic Antibodies: Contributions from Engineering and Expression in Escherichia Coli (pages 103–117)

      Andreas Plückthun and Jörg Stadlmüller

    10. The Generation of Antibody Combining Sites Containing Catalytic Residues (pages 118–144)

      Kevan M. Shokat and Peter G. Schultz

    11. Screening Combinatorial Antibody Libraries for Catalytic Acyl Transfer Reactions (pages 145–155)

      Lakshmi Sastry, Monica Mubaraki, Kim D. Janda, Steve J. Benkovic and Richard A. Lerner

    12. Binding and Multiple Hydrolytic Sites in Epitopes Recognized by Catalytic Anti-Peptide Antibodies (pages 156–173)

      Sudhir Paul, Donald R. Johnson and Richard Massey

    13. Antibody Catalysis of Carbon-Carbon Bond Formation (pages 174–187)

      Donald Hilvert

    14. Characterization of the Mechanism of Action of a Catalytic Antibody (pages 188–200)

      Mark T. Martin, Allen R. Schantz, Peter G. Schultz and Anthony R. Rees

    15. Catalytic Antibodies: A New Window on Protein Chemistry (pages 201–210)

      Colin J. Suckling, Catriona M. Tedford, George R. Proctor, Abedawn I. Khalaf, Laura M. Bence and William H. Stimson

    16. Expanded Transition State Analogues (pages 211–226)

      G. Michael Blackburn, Gillian Kingsbury, Sriyani Jayaweera and Dennis R. Burton

    17. Tritylase Antibodies (pages 227–245)

      Brent L. Iverson, Sheila A. Iverson, Katherine E. Cameron, Guiti K. Jahangiri, Dahna S. Pasternak and Richard A. Lerner

    18. Summary (pages 246–248)

      W. P. Jencks

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      Index of Contributors (pages 249–250)

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      Subject Index (pages 251–259)

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