Ciba Foundation Symposium 167 - Polyfunctional Cytokines: IL-6 and LIF

Copyright © Ciba Foundation 1992

Ciba Foundation Symposium 167 - Polyfunctional Cytokines: IL-6 and LIF

Editor(s): Gregory R. Bock, Joan Marsh, Kate Widdows

Published Online: 28 SEP 2007

Print ISBN: 9780471934394

Online ISBN: 9780470514269

DOI: 10.1002/9780470514269

About this Book

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About The Product

Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–x)

    2. Introduction (pages 1–4)

      Donald Metcalf

    3. The Molecular Biology of Interleukin 6 and its Receptor (pages 5–23)

      Tadamitsu Kishimoto, Masahiko Hibi, Masaaki Murakami, Masashi Narazaki, Mikiyoshi Saito and Tetsuya Taga

    4. Molecular Biology of the Leukaemia Inhibitory Factor Gene (pages 24–46)

      Nicholas M. Gough, Tracy A. Willson, Jürgen Stahl and Melissa A. Brown

    5. Regulation of Expression of the Interleukin 6 Gene: Structure and Function of the Transcription Factor NF-IL6 (pages 47–67)

      Shizuo Akira, Hiroshi Isshiki, Toshihiro Nakajima, Shigemi Kinoshita, Yukihiro Nishio, Shunji Natsuka and Tadamitsu Kishimoto

    6. The Action of Interleukin 6 on Lymphoid Populations (pages 68–79)

      Lucien A. Aarden and Cees van Kooten

    7. Regulation of Leukaemic Cells by Interleukin 6 and Leukaemia Inhibitory Factor (pages 80–99)

      Joseph Lotem and Leo Sachs

    8. The Action of Interleukin 6 and Leukaemia Inhibitory Factor on Liver Cells (pages 100–124)

      H. Baumann, S. Marinkovic-Pajovic, K.-A. Won, V. E. Jones, S. P. Campos, G. P. Jahreis and K. K. Morella

    9. Further Studies of the Distribution of CDF/LIF mRNA (pages 125–140)

      Paul H. Patterson and Ming-Ji Fann

    10. Leukaemia Inhibitory Factor and Bone Cell Function (pages 141–159)

      T. J. Martin, E. H. Allan, R. S. Evely and I. R. Reid

    11. The Role of Interleukin 6 in Megakaryocyte Formation, Megakaryocyte Development and Platelet Production (pages 160–173)

      N. Williams, I. Bertoncello, H. Jackson, J. Arnold and H. Kavnoudias

    12. Actions of Leukaemia Inhibitory Factor on Megakaryocyte and Platelet Formation (pages 174–187)

      D. Metcalf, P. Waring and N. A. Nicola

    13. The Role of Interleukin 6 in Plasmacytomagenesis (pages 188–204)

      Toshio Hirano, Sachiko Suematsu, Taiji Matsusaka, Tadashi Matsuda and Tadamitsu Kishimoto

    14. Interleukin 6 Determination in the Detection of Microbial Invasion of the Amniotic Cavity (pages 205–226)

      Roberto Romero, Waldo Sepulveda, John S. Kenney, Linda E. Archer, Anthony C. Allison and Pravinkumar B. Sehgal

    15. Distribution and Binding Properties of Receptors for Leukaemia Inhibitory Factor (pages 227–244)

      Douglas J. Hilton, Nicos A. Nicola and Donald Metcalf

    16. Reconstitution of High Affinity Leukaemia Inhibitory Factor (LIF) Receptors in Haemopoietic Cells Transfected with the Cloned Human LIF Receptor (pages 245–266)

      David P. Gearing, Tim VandenBos, M. Patricia Beckmann, Catherine J. Thut, Michael R. Comeau, Bruce Mosley and Steven F. Ziegler

    17. Summing-Up (pages 267–268)

      Donald Metcalf

    18. You have free access to this content
      Index of Contributors (pages 269–270)

    19. You have free access to this content
      Subject Index (pages 271–279)

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