Ciba Foundation Symposium 190 - Somatostatin and its Receptors

Copyright © Ciba Foundation 1995

Ciba Foundation Symposium 190 - Somatostatin and its Receptors

Editor(s): Derek J. Chadwick, Gail Cardew

Published Online: 28 SEP 2007

Print ISBN: 9780471953821

Online ISBN: 9780470514733

DOI: 10.1002/9780470514733

About this Book

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About The Product

This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction (pages 1–6)

      Seymour Reichlin

    3. Regulation of Somatostatin Gene Transcription by CAMP (pages 7–25)

      M. Montminy, P. Brindle, J. Arias, K. Ferreri and R. Armstrong

    4. Processing and Intracellular Targeting of Prosomatostatin-Derived Peptides: the Role of Mammalian Endoproteases (pages 26–50)

      Yogesh C. Patel and Aristea Galanopoulou

    5. Anatomical Localization and Regulation of Somatostatin Gene Expression in the Basal Ganglia and its Clinical Implications (pages 51–64)

      Marie-Françoise Chesselet, Jean-Jacques Soghomonian and Pascal Salin

    6. Molecular Biology of Somatostatin Receptors (pages 65–88)

      Graeme I. Bell, Kazuki Yasuda, Haeyoung Kong, Susan F. Law, Karen Raynor and Terry Reisine

    7. Characterization of Somatostatin Receptor Subtypes (pages 89–110)

      Ch. Bruns, G. Weckbecker, F. Raulf, H. Lübbert and D. Hoyer

    8. Regulation of Somatostatin Receptor mRNA Expression (pages 111–126)

      Michael Berelowitz, Yun Xu, Jinfen Song and John F. Bruno

    9. Transient Expression of Somatostatin Receptors in the Brain During Development (pages 127–141)

      Philippe Leroux, Corinne Bodenant, Evelina Bologna, Bruno Gonzalez and Hubert Vaudry

    10. Expression of sstr1 and sstr2 in Rat Hypothalamus: Correlation with Receptor Binding and Distribution of Growth Hormone Regulatory Peptides (pages 142–159)

      Alain Beaudet and Gloria S. Tannenbaum

    11. Interaction of Somatostatin Receptors with G Proteins and Cellular Effector Systems (pages 160–170)

      Terry Reisine, Donna Woulfe, Karen Raynor, Haeyoung Kong, Jennifer Heerding, John Hines, Melanie Tallent and Susan Law

    12. Somatostatin Modulates Voltage-Dependent Ca2+ Channels in Gh3 Cells Via a Specific Go Splice Variant (pages 171–186)

      C. Kleuss

    13. A Tyrosine Phosphatase is Associated with the Somatostatin Receptor (pages 187–203)

      N. Delesque, L. Buscail, J. P. Estève, I. Rauly, M. Zeggari, N. Saint-Laurent, G. I. Bell, A. V. Schally, N. Vaysse and C. Susini

    14. Function and Regulation of Somatostatin Receptor Subtypes (pages 204–221)

      Agnes Schonbrunn, Yi-Zhong Gu, Patricia J. Brown and David Loose-Mitchell

    15. Somatostatin Receptors: Clinical Implications for Endocrinology and Oncology (pages 222–239)

      S. W. J. Lamberts, W. W. de Herder, P. M. van Koetsveld, J. W. Koper, A. J. van der Lely, H. A. Visser-Wisselaar and L. J. Hofland

    16. Somatostatin Analogues and Multiple Receptors: Possible Physiological Roles (pages 240–257)

      David H. Coy and Wocjiech J. Rossowski

    17. Summary (pages 258–260)

      Seymour Reichlin

    18. You have free access to this content
      Appendix (pages 261–262)

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      Index of Contributers (pages 263–264)

    20. You have free access to this content
      Subject Index (pages 265–274)

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