Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Copyright © Ciba Foundation 1996

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Editor(s): Gregory R. Bock, Jamie A. Goode

Published Online: 28 SEP 2007

Print ISBN: 9780471957218

Online ISBN: 9780470514863

DOI: 10.1002/9780470514863

About this Book

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About The Product

Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–ix)

    2. Introduction (pages 1–2)

      John A. Kessler and Thomas A. Van De Water

    3. Motor Neuron Disease and Model Systems: Aetiologies, Mechanisms and Therapies (pages 3–17)

      Donald L. Price, Vassilis E. Koliatsos, Philip C.-Y. Wong, Carlos A. Pardo, David R. Borchelt, Michael K. Lee, Don W. Cleveland, John W. Griffin, Paul N. Hoffman, Linda C. Cork and Sangram S. Sisodia

    4. Potential Utility of rhIGF-1 in Neuromuscular and/or Degenerative Disease (pages 18–38)

      J. L. Vaught, P. C. Contreras, M. A. Glicksman and N. T. Neff

    5. Therapeutic Potential of the Neurotrophins and Neurotrophin—CNTF Combinations in Peripheral Neuropathies and Motor Neuron Diseases (pages 39–53)

      Ronald M. Lindsay

    6. Development of Neurotrophic Factor Therapy for Alzheimer's Disease (pages 54–69)

      Franz Hefti, Mark P. Armanini, Klaus D. Beck, Ingrid W. Caras, Karen S. Chen, Paul J. Godowski, Laurie J. Goodman, R. Glenn Hammonds, Melanie R. Mark, Paul Moran, Merry C. Nishimura, Heidi S. Phillips, Ai Shih, Janet Valverde and John W. Winslow

    7. Growth Factor Function in the Development and Maintenance of Midbrain Dopaminergic Neurons: Concepts, Facts and Prospects for TGF-β (pages 70–84)

      Klaus Unsicker, Clemens Suter-Crazzalora and Kerstin Krieglstein

    8. Somatic Gene Therapy for Nervous System Disease (pages 85–97)

      Mark H. Tuszynski and Fred H. Gage

    9. Neurotrophic Factors in the Treatment of Peripheral Neuropathy (pages 98–119)

      Stuart C. Apfel and John A. Kessler

    10. Growth Factors in the Treatment of Degenerative Retinal Disorders (pages 120–134)

      Thomas A. Reh, Kathryn McCabe, Matthew W. Kelley and Olivia Bermingham-McDonogh

    11. Effects of Neurotrophins on the Survival and Regrowth of Injured Retinal Neurons (pages 135–148)

      A. J. Aguayo, D. B. Clarke, T. N. Jelsma, P. Kittlerova, H. C. Hyman Friedman and G. M. Bray

    12. Neurotrophic Factors as Pharmacological Agents for the Treatment of Injured Auditory Neurons (pages 149–166)

      Thomas R. Van De Water, Hinrich Staecker, Patrik Ernfors, Gustave Moonen and Philippe P. Lefebvre

    13. Growth Factors as Potential Drugs for the Sensory Epithelia of the Ear (pages 167–187)

      Jeffrey T. Corwin, Mark E. Warchol, Linda D. Saffer, James E. Finley, Rende Gu and Paul R. Lambert

    14. Factors Affecting Neuronal Birth and Death in the Mammalian Olfactory Epithelium (pages 188–210)

      Anne L. Calof, J. David Holcomb, Jeffrey S. Mumm, Nobuko Hagiwara, Phu Tran, Kirk M. Smith and David Shelton

    15. The Problems of Delivering Neuroactive Molecules to the CNS (pages 211–239)

      Sanda A. Tan and Patrick Aebischer

    16. Closing Remarks (page 240)

      John A. Kessler

    17. You have free access to this content
      Index of Contributors (pages 241–242)

    18. You have free access to this content
      Subject Index (pages 243–253)

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