Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms

Copyright © Ciba Foundation 1996

Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms

Editor(s): Derek J. Chadwick, Jamie A. Goode

Published Online: 28 SEP 2007

Print ISBN: 9780471961253

Online ISBN: 9780470514900

DOI: 10.1002/9780470514900

About this Book

Product Information

About The Product

Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.

Table of contents

    1. You have free access to this content
      Front Matter (pages i–x)

    2. P2 Purinoceptors: Historical Perspective and Classification (pages 1–34)

      Geoffrey Burnstock

    3. The Diadenosine Polyphosphate Receptors: P2D Purinoceptors (pages 35–52)

      M. Teresa Miras-Portugal, Enrique Castro, Jesus Mateo and Jesus Pintor

    4. P2T Purinoceptors: ADP Receptors on Platelets (pages 53–70)

      Susanna M. O. Hourani and David A. Hall

    5. P2Z Purinoceptors (pages 71–90)

      S. E. Hickman, C. E. Semrad and S. C. Silverstein

    6. P2X Receptors: A Third Major Class of Ligand-Gated Ion Channels (pages 91–109)

      R. Alan North

    7. P2 Purinoceptors and Pyrimidinoceptors of Catecholamine-Producing Cells and Immunocytes (pages 110–129)

      P. Illes, K. Nieber, R. Fröhlich and W. Nörenberg

    8. Trophic Actions of Extracellular ATP on Astrocytes, Synergistic Interactions with Fibroblast Growth Factors and Underlying Signal Transduction Mechanisms (pages 130–141)

      Joseph T. Neary

    9. Trophic Roles of P2 Purinoceptors in Central Nervous System Astroglial Cells (pages 142–148)

      Maria P. Abbracchio, Stefania Ceruti, Chiara Bolego, Lina Puglisi, Geoffrey Burnstock and Flaminio Cattabeni

    10. Transduction Mechanisms of P2Z Purinoceptors (pages 149–165)

      J. S. Wiley, J. R. Chen, M. S. Snook, C. E. Gargett and G. P. Jamieson

    11. The Diverse Series of Recombinant P2Y Purinoceptors (pages 166–192)

      E. A. Barnard, T. E. Webb, J. Simon and S. P. Kunapuli

    12. P2U Purinoceptors: cDNA Cloning, Signal Transduction Mechanisms and Structure–Function Analysis (pages 193–207)

      Kevin D. Lustig, Gary A. Weisman, John T. Turner, Richard Garrad, Andrew K. Shiau and Laurie Erb

    13. Functional Properties of Native and Cloned P2X Receptors (pages 208–222)

      Annmarie Surprenant

    14. ATP as a Co-Transmitter with Noradrenaline in Sympathetic Nerves—Function and Fate (pages 223–238)

      Charles Kennedy, Gerald J. McLaren, Tim D. Westfall and Peter Sneddon

    15. ATP Release and its Prejunctional Modulation (pages 239–265)

      Klaus Starke, Ivar von Kügelgen, Bernd Driessen and Ralph Bültmann

    16. Involvement of Distinct Receptors in the Actions of Extracellular Uridine Nucleotides (pages 266–277)

      Jean-Marie Boeynaems, Didier Communi, Sabine Pirotton, Serge Motte and Marc Parmentier

    17. Features of P2X Receptor-Mediated Synapses in the Rat Brain: Why doesn't ATP Kill the Postsynaptic Cell? (pages 278–289)

      Frances A. Edwards

    18. P2 Purinoceptors in the Immune System (pages 290–308)

      Francesco Di Virgilio, Davide Ferrari, Simonetta Falzoni, Paola Chiozzi, Maddalena Munerati, Thomas H. Steinberg and Olavio R. Baricordi

    19. Challenges in Developing P2 Purinoceptor-Based Therapeutics (pages 309–321)

      Michael Williams

    20. Summing-Up (pages 322–323)

      Geoffrey Burnstock

    21. You have free access to this content
      Index of Contributors (pages 324–325)

    22. You have free access to this content
      Subject Index (pages 326–337)

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