Ciba Foundation Symposium 199 - The Nature and Origin of Amyloid Fibrils

Ciba Foundation Symposium 199 - The Nature and Origin of Amyloid Fibrils

Editor(s): Gregory R. Bock, Jamie A . Goode

Published Online: 28 SEP 2007

Print ISBN: 9780471963615

Online ISBN: 9780470514924

DOI: 10.1002/9780470514924

About this Book

Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.

Table of contents

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    2. A Molecular Model of the Amyloid Fibril (pages 6–21)

      Colin C. F. Blake, Louise C. Serpell, Margaret Sunde, Ola Sandgren and Erik Lundgren

    3. Modulating Conformational Factors in Transthyretin Amyloid (pages 47–57)

      M. J. M. Saraiva, M. R. Almeida, I. L. Alves, M. J. Bonifácio, A. M. Damas, J. A. Palha, G. Goldsteins and E. Lundgren

    4. Molecular Mechanisms of Fibrillogenesis and the Protective Role of Amyloid P Component: Two Possible Avenues for Therapy (pages 73–103)

      M. B. Pepys, G. A. Tennent, D. R. Booth, V. Bellotti, L. B. Lovat, S. Y. Tan, M. R. Persey, W. L. Hutchinson, S. E. Booth, S. Madhoo, A. K. Soutart, P. N. Hawkins, R. Van Zyl-Smit, J. M. Campistol, P. E. Fraser, S. E. Radford, C. V. Robinson, M. Sunde, L. C. Serpell and C. C. F. Blake

    5. Metabolism of Amyloid Proteins (pages 104–118)

      M. D. Benson, B. Kluve-Beckerman, J. J. Liepnieks, J. R. Murrell, D. Hanes and T. Uemichi

    6. Apolipoprotein E and Amyloidogenesis (pages 132–145)

      Blas Frangione, Eduardo M. Castaño, Thomas Wisniewski, Jorge Ghiso, Frances Prelli and Ruben Vidal

    7. β-Amyloid Precursor Protein and Early-Onset Alzheimer's Disease (pages 170–180)

      Lydia Hendriks, Chris De Jonghe, Patrick Cras, Jean-Jacques Martin and Christine Van Broeckhoven

    8. Prion Protein Amyloid: Separation of Scrapie Infectivity from PrP Polymers (pages 181–204)

      Holger Wille, Michael A. Baldwin, Fred E. Cohen, Stephen J. DeArmond and Stanley B. Prusiner

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