Editor(s): Saura C. Sahu

Published Online: 27 FEB 2008

Print ISBN: 9780470057162

Online ISBN: 9780470516751

DOI: 10.1002/9780470516751

About this Book

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.

Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.

This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.

Table of contents

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  1. Section 1: Models for Hepatotoxicity Testing

    1. Chapter 1

      Current in vitro Models to Study Drug-Induced Liver Injury (pages 1–55)

      Julio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O'Brien and Stephen C. Storm

    2. Chapter 2

      Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery (pages 57–68)

      Ikuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa

  2. Section 2: Hepatocyte Cultures

  3. Section 3: Biomarkers of Hepatotoxicity

  4. Section 4: Mechanisms of Hepatotoxicity

    1. Chapter 12

      Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis (pages 313–340)

      James E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip

    2. Chapter 15

      Bile Acids as Modulators of Apoptosis (pages 391–419)

      Rui E. Castro, Susana Solá, Clifford J. Steer and Cecília M.P. Rodrigues

    3. Chapter 16

      Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP) (pages 421–446)

      Christoph Funk, Johannes Noé, Renée Portmann, Rubén Alvarez-Sánchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze

  5. Section 5: Genomics of Hepatotoxicity

  6. Section 6: Gender Differences in Hepatotoxicity

  7. Section 7: Hepatotoxicity and Hepatocarcinogenicity

  8. Section 8: Hepatotoxicity and Botanical Supplements

  9. Section 9: Risk Analysis of Hepatotoxins

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