Iminosugars: From Synthesis to Therapeutic Applications

Iminosugars: From Synthesis to Therapeutic Applications

Editor(s): Philippe Compain, Olivier R. Martin

Published Online: 5 MAR 2008

Print ISBN: 9780470033913

Online ISBN: 9780470517437

DOI: 10.1002/9780470517437

About this Book

Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.

Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances.

Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Table of contents

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    3. Chapter 7

      Iminosugar-Based Glycosyltransferase Inhibitors (pages 153–176)

      Lisa J. Whalen, William A. Greenberg, Michael L. Mitchell and Chi-Huey Wong

    4. Chapter 9

      Iminosugars as Antiviral Agents (pages 209–224)

      Pamela A. Norton, Baohua Gu and Timothy M. Block

    5. Chapter 13

      Medicinal use of Iminosugars (pages 295–326)

      Timothy M. Cox, Frances M. Platt and Johannes M. F. G. Aerts

    6. Chapter 14

      Tables of Iminosugars, Their Biological Activities and their Potential as Therapeutic Agents (pages 327–455)

      Philippe Compain, Valérie Desvergnes, Virginie Liautard, Christelle Pillard and Sylvestre Toumieux

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