Current Protocols in Chemical Biology

Current Protocols in Chemical Biology

Online ISBN: 9780470559277

DOI: 10.1002/9780470559277

Mission Statement

Reproducible laboratory methods are the foundation of scientific discovery. Yet, nuances critical for success are not captured in the primary literature but exist only as part of a lab’s oral tradition. Current Protocols in Chemical Biology (CPCh) provides clear step-by-step instructions for validated protocols as well as enlightening overviews for researchers who need specialized chemical techniques and tools for their studies of biology and drug design. CPCh describes these chemical tools, including small-molecule design, synthesis, derivatization, handling, and detection. Advances in laboratory automation, robotics, and medicinal chemistry are described as applied to high-throughput screening (HTS) methods. Also included are methods for modification of proteins, nucleic acids, carbohydrates and lipids for their use as tools in the study of particular biological systems. Written by experts and extensively edited, CPCh articles describe applications, assumptions, troubleshooting, time considerations, and representative results.


medicinal chemists, combinatorial chemists, proteomics, pharmacologists, biochemists, glycobiologists, chemical geneticists, molecular biologists, cell biologists, and cytometrists


small molecule, drug discovery, protein engineering, nucleic acid, lipid, carbohydrate, high throughput screening, synthesis, protocol