Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Editor(s): Marina Ramirez-Alvarado, Jeffery W. Kelly, Christopher M. Dobson

Published Online: 2 JUL 2010

Print ISBN: 9780471799283

Online ISBN: 9780470572702

DOI: 10.1002/9780470572702

About this Book

An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Table of contents

    1. You have free access to this content
    1. You have free access to this content
  1. Part I: Principles of Protein Misfolding

    1. Chapter 1

      Why Proteins Misfold (pages 1–20)

      Silvia Campioni, Elodie Monsellier and Fabrizio Chiti

    2. Chapter 3

      Role of Molecular Chaperones in Protein Folding (pages 47–72)

      Kausik Chakraborty, Florian Georgescauld, Manajit Hayer-Hartl and F. Ulrich Hartl

    3. Chapter 7

      Role of Posttranslational Modifications in Amyloid Formation (pages 131–144)

      Andisheh Abedini, Ruchi Gupta, Peter Marek, Fanling Meng, Daniel P. Raleigh, Humeyra Taskent and Sylvia Tracz

  2. Part II: Protein Misfolding Disease: Gain-of-Function and Loss-of-Function Diseases

    1. Chapter 16

      Hemodialysis-Related Amyloidosis (pages 347–379)

      David P. Smith, Alison E. Ashcroft and Sheena E. Radford

    2. Chapter 19

      Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease (pages 425–452)

      William E. Balch, Ineke Braakman, Jeff Brodsky, Raymond Frizzell, William Guggino, Gergely L. Lukacs, Christopher Penland, Harvey Pollard, William Skach, Eric Sorscher and Philip Thomas

  3. Part III: Role of Accessory Molecules and Risk Factors

  4. Part IV: Medical Aspects of Disease: Diagnosis and Current Therapies

  5. Part V: Approaches for New and Emerging Therapies

    1. Chapter 45

      Understanding and Ameliorating the TTR Amyloidoses (pages 967–1003)

      Steven M. Johnson, Luke Wiseman, Johan F. Paulsson, Sungwook Choi, Evan T. Powers, Joel N. Buxbaum and Jeffery W. Kelly

    1. You have free access to this content