Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Editor(s): Chao Han, Charles B. Davis, Binghe Wang

Published Online: 7 JAN 2010

Print ISBN: 9780470044919

Online ISBN: 9780470574898

DOI: 10.1002/9780470574898

About this Book

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Table of contents

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  1. Part I: Pharmacokinetics and Drug Metabolism in Drug Discovery

  2. Part II: Integration of Pharmaceutical Development into Drug Discovery

  3. Part III: Predictive Safety Assessment in Drug Discovery

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