Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders

Editor(s): Arthur Gomtsyan, Connie R. Faltynek

Published Online: 22 FEB 2010

Print ISBN: 9780470175576

Online ISBN: 9780470588284

DOI: 10.1002/9780470588284

About this Book

Examines the emerging therapeutic role of TRPV1

TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands.

With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses:

  • Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research

  • The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer

  • The development of analgesic drugs

  • Other applications for TRPV1, including the treatment of respiratory disease and diabetes

Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.

Table of contents

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    1. You have free access to this content
  1. Part I: Introduction to the TRP Channels

    1. Chapter 4

      TRPV1 Genetics (pages 134–149)

      Ruslan Dorfman, Hubert Tsui, Michael W. Salter and H.-Michael Dosch

  2. Part II: Role for TRPV1 in Pain States

    1. Chapter 5

      TRPV1 and Inflammatory Pain (pages 151–174)

      Anindya Bhattacharya, Sonya G. Lehto and Narender R. Gavva

  3. Part III: TRPV1 Antagonists and Agonists as Novel Analgesic Drugs

  4. Part IV: Role for TRPV1 in Other Physiological Processes besides Pain Transmission

    1. Chapter 14

      The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools? (pages 349–402)

      Andras Garami, Maria C. Almeida, Tatiane B. Nucci, Tamara Hew-Butler, Renato N. Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison and Andrej A. Romanovsky

    2. Chapter 15

      The Role of TRPV1 in Respiratory Diseases (pages 403–422)

      Serena Materazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani and Pierangelo Geppetti

    3. Chapter 16

      The Role of TRPV1 in Diabetes (pages 423–448)

      Hubert Tsui, Ruslan Dorfman, Michael W. Salter and H.-michael Dosch

    1. You have free access to this content
    1. You have free access to this content

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