Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Editor(s): Satinder Ahuja

Published Online: 28 OCT 2010 11:07AM EST

Print ISBN: 9780470406915

Online ISBN: 9780470608661

DOI: 10.1002/9780470608661

About this Book

Discusses chiral separations and offers guidance for selecting the optimum method for desired results

Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development.

Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book:

  • Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis

  • Deals with the impact of chirality on the biological activity of small and large molecules

  • Provides detailed information on useful chiral stationary phases (CSPs) for HPLC

  • Includes handy information on selection of an appropriate CSP, including mechanistic studies

  • Offers strategies for fast method development with HPLC, SFC, and CE

  • Discusses preparatory methods utilized in the pharmaceutical industry

With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.

Table of contents

    1. You have free access to this content
    2. You have free access to this content
    3. Chapter 13

      Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers (pages 417–427)

      Christopher J. Welch, Derek H. Henderson, William R. Leonard, Mirlinda Biba, Mike Zacuto, Fred Fleitz, Amude Kassim, Cheng-yi Chen and Peter Sajonz

    4. You have free access to this content

SEARCH