Cancer Risk Assessment

Copyright © 2010 John Wiley & Sons, Inc.

Cancer Risk Assessment

Editor(s): Ching-Hung Hsu, Todd Stedeford

Published Online: 5 AUG 2010

Print ISBN: 9780470238226

Online ISBN: 9780470622728

DOI: 10.1002/9780470622728

About this Book

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xxxi)

  2. Part I: Cancer Risk Assessment, Science Policy, and Regulatory Frameworks

    1. Chapter 1

      Cancer Risk Assessment (pages 1–22)

      Elizabeth L. Anderson, Kimberly Lowe and Paul Turnham

    2. Chapter 2

      Science Policy and Cancer Risk Assessment (pages 23–36)

      Gary E. Marchant

    3. Chapter 3

      Hazard and Risk Assessment of Chemical Carcinogenicity within a Regulatory Context (pages 37–65)

      Henk Tennekes, Virginia A. Gretton and Todd Stedeford

    4. Chapter 4

      Use of Cancer Risk Assessments in Determination of Regulatory Standards (pages 66–95)

      Robert A. Howd and Anna M. Fan

  3. Part II: Cancer Biology and Toxicology

    1. Chapter 5

      The Interplay of Cancer and Biology (pages 97–167)

      James W. Holder

    2. Chapter 6

      Chemical Carcinogenesis: A Brief History of Its Concepts with a Focus on Polycyclic Aromatic Hydrocarbons (pages 168–190)

      Stephen Nesnow

    3. Chapter 7

      Hormesis and Cancer Risks: Issues and Resolution (pages 191–206)

      Paolo F. Ricci and Edward J. Calabrese

    4. Chapter 8

      Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies (pages 207–221)

      Shoji Fukushima, Min Wei, Anna Kakehashi and Hideki Wanibuchi

  4. Part III: Genetic Toxicology, Testing Guidelines and Regulations, and Novel Assays

    1. Chapter 9

      Development of Genetic Toxicology Testing and its Incorporation into Regulatory Health Effects Test Requirements (pages 223–237)

      Errol Zeiger

    2. Chapter 10

      Genetic Toxicology Testing Guidelines and Regulations (pages 238–271)

      Lutz Müller and Hans-Jörg Martus

    3. Chapter 11

      In Vitro Genotox Assays (pages 272–288)

      David Kirkland and David Gatehouse

    4. Chapter 12

      In Vivo Genotoxicity Assays (pages 289–359)

      Véronique Thybaud

  5. Part IV: Assessing the Human Relevance of Chemical - Induced Tumors

    1. Chapter 13

      Framework Analysis for Determining Mode of Action and Human Relevance (pages 361–377)

      R. Julian Preston

    2. Chapter 14

      Experimental Animal Studies and Carcinogenicity (pages 378–396)

      Mary Elizabeth (Bette) Meek

    3. Chapter 15

      Cancer Epidemiology (pages 397–418)

      Herman J. Gibb and Jessie P. Buckley

    4. Chapter 16

      Rodent Hepatocarcinogenesis (pages 419–438)

      James E. Klaunig

    5. Chapter 17

      Mode of Action Analysis and Human Relevance of Liver Tumors Induced by PPARα Activation (pages 439–481)

      J. Christopher Corton

    6. Chapter 18

      Alpha2U-Globulin Nephropathy and Chronic Progressive Nephropathy as Modes of Action for Renal Tubule Tumor Induction in Rats, and Their Possible Interaction (pages 482–500)

      Edward A. Lock and Gordon C. Hard

    7. Chapter 19

      Urinary Tract Calculi and Bladder Tumors (pages 501–514)

      Samuel M. Cohen, Lora L. Arnold and Shugo Suzuki

  6. Part V: Methods for Informing Cancer Risk Quantification

    1. Chapter 20

      (Q)Sar Analysis of Genotoxic and Nongenotoxic Carcinogens: A State-of-the-Art Overview (pages 515–556)

      Yin-Tak Woo and David Y. Lai

    2. Chapter 21

      Physiologically Based Pharmacokinetic (PBPK) Models in Cancer Risk Assessment (pages 557–585)

      Mathieu Valcke and Kannan Krishnan

    3. Chapter 22

      Genomics and its Role in Cancer Risk Assessment (pages 586–596)

      Banalata Sen, Douglas C. Wolf and Vicki Dellarco

    4. Chapter 23

      Computational Toxicology in Cancer Risk Assessment (pages 597–612)

      Jerry N. Blancato

  7. Part VI: General Approaches for Quantifying Cancer Risks

    1. Chapter 24

      Linear Low-Dose Extrapolations (pages 613–635)

      Michael Dourson and Lynne Haber

    2. Chapter 25

      Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens (pages 636–658)

      Rafael Meza, Jihyoun Jeon and Suresh H. Moolgavkar

    3. Chapter 26

      Nonlinear Low-Dose Extrapolations (pages 659–680)

      Ari S. Lewis and Barbara D. Beck

    4. Chapter 27

      Cancer Risk Assessment: More Uncertain than We Thought (pages 681–698)

      Edmund A. C. Crouch

    5. Chapter 28

      Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies (pages 699–715)

      Amy E. Brix, Jerry F. Hardisty and Ernest E. McConnell

    6. Chapter 29

      Cancer Risk Based on an Individual Tumor Type or Summing of Tumors (pages 716–735)

      Andrew G. Salmon and Lindsey A. Roth

    7. Chapter 30

      Exposure Reconstruction and Cancer Risk Estimate Derivation (pages 736–784)

      Shannon Gaffney, Jennifer Sahmel, Kathryn D. Devlin and Dennis J. Paustenbach

    1. You have free access to this content
      Index (pages 785–824)

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