GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions

GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions

Editor(s): Annette Gilchrist

Published Online: 15 JUL 2010

Print ISBN: 9780470307786

Online ISBN: 9780470627327

DOI: 10.1002/9780470627327

About this Book

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs.  Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      The Evolving Pharmacology of GPCRs (pages 27–60)

      Lauren T. May, Nicholas D. Holliday and Stephen J. Hill

    3. Chapter 3

      The Emergence of Allosteric Modulators for G Protein-Coupled Receptors (pages 61–87)

      Karen J. Gregory, Celine Valant, John Simms, Patrick M. Sexton and Arthur Christopoulos

    4. Chapter 7

      Past and Future Strategies for GPCR Deorphanization (pages 165–190)

      Angélique Levoye, Nathalie Clement, Elodie Tenconi and Ralf Jockers

    5. You have free access to this content

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