Genetic Effects on Environmental Vulnerability to Disease: Novartis Foundation Symposium 293

Genetic Effects on Environmental Vulnerability to Disease: Novartis Foundation Symposium 293

Editor(s): Michael Rutter

Published Online: 12 AUG 2008

Print ISBN: 9780470777800

Online ISBN: 9780470696781

DOI: 10.1002/9780470696781

Series Editor(s): Novartis Foundation

About this Book

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens.

This book brings together contributions from experts from multiple disciplines who discuss:

  • How epidemiological cohort studies can better integrate physiological (mechanistic) measures;
  • How best to characterise subjects' vulnerability versus resilience by moving beyond single genetic polymorphisms;
  • How gene hunters can benefit from recruiting samples selected for known exposures;
  • How environmental pathogens can be used as tools for gene hunting;
  • How to deal with potential spurious (statistical) interactions, and
  • How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

Table of contents

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    3. Chapter 5

      Role of Gene–Stress Interactions in Gene-Finding Studies (pages 71–86)

      Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman

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