General, Applied and Systems Toxicology

General, Applied and Systems Toxicology

Online ISBN: 9780470744307

DOI: 10.1002/9780470744307

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  1. Basic Science
    1. Basic Elements of Toxicology
    2. Acute Toxicity
    3. Repeated Exposure Toxicity
    4. Biotransformation of Xenobiotics
    5. Toxicokinetics of Xenobiotic and Metabolite Distribution and Excretion
    6. Toxicokinetics
    7. Physiologically Based Pharmacokinetic Modelling
    8. Toxicology of Chemical Mixtures
    9. Evaluation of Toxicological Interactions for the Dose-Response Assessment of Chemical Mixtures
  2. Molecular and Cellular Aspects of Toxicology
    1. Molecular and Cellular Concepts in Toxicology
    2. Cell Death and Apoptosis
    3. Introduction to Mitochondrial Toxicity
    4. Toxicity of Peroxisome Proliferators
    5. Cellular Tight Junctions as Mediators of Adverse Effects
    6. Reactive Oxygen Species in the Induction of Toxicity
    7. Glutathione and Glutathione-S-Transferase in Detoxification Mechanisms
    8. Nitric Oxide Pathways in Toxic Responses
    9. A Metabolomic Perspective of Small Molecule Toxicity
    10. Xenobiotic-Induced Inflammation: Pathogenesis and Mediators
    11. Chemokines as Mediators of Toxicant-Induced Inflammation and Fibrosis
    12. Toxicogenomics and the Evolution of Systems Toxicology
    13. Endocrine Disruption in Toxic Responses
  3. Factors Influencing Toxicology
    1. Environmental and Endogenous Factors Determining the Expression of Toxicity
    2. Chronotoxicology
    3. Effects of Chirality on Toxicity
    4. The Influence of Temperature on Toxicity
    5. Development of Tolerance to the Toxicity of Xenobiotics
  4. Methodology
    1. Statistics for Toxicology
    2. Pathological Techniques in Toxicology
    3. Clinical Chemistry in Toxicity Testing: Scope and Methods
    4. Haematology and Toxicology
    5. Imaging Techniques in Neurotoxicology Research and Development
    6. Alternatives to In vivo Studies in Toxicology
    7. Antidotal Studies
    8. Toxicity Data Obtained From Human Studies
    9. Significance of Biochemical Markers in Applied Toxicology
    10. Oncology Biomarkers
    11. Quality Assurance in Toxicology Studies
    12. Animal Welfare in the Toxicology Laboratory
    13. Chemical and Biological Occupational Hazards in the Toxicology Laboratory
    14. Information Resources for Toxicology
  5. Toxicity by Routes
    1. Toxicities Associated with Parenteral Nutrition
    2. Peroral Toxicity
    3. Cutaneous Toxicology
    4. Inhalation Toxicity
    5. Mixed Routes of Exposure
  6. Target Organ and Tissue Toxicity
    1. Neurotoxicology
    2. The Role of Behavioural Toxicity in Risk Assessment
    3. Peripheral Chemosensory Irritation: Fundamentals, Investigation and Applied Considerations
    4. Responses of the Kidney to Toxic Compounds
    5. Allergic Asthma and Rhinitis: Toxicological Considerations
    6. Laboratory Recognition of Potential Xenobiotic Respiratory Sensitizers
    7. Ophthalmic Toxicology
    8. Cutaneous Toxicology
    9. Photoallergy
    10. Ototoxicity
    11. Cardiac Toxicology
    12. Cardiac Toxicity of Anthracyclines
    13. Hepatotoxicity
    14. Toxicology of the Exocrine Pancreas
    15. Skeletal Muscle Toxicology
    16. Cartilage and Bone as Target Tissues for Toxic Materials
    17. Toxicology of the Endocrine System
    18. Immunotoxicology
    19. Phototoxicology
  7. Genetic Toxicology, Oncogenesis, Developmental and Reproductive Toxicology
    1. Mutagenesis
    2. Cytogenetics
    3. Genetic Toxicology Testing and its Relevance to Human Risk and Safety Evaluation
    4. Carcinogenesis and Carcinogens that are also Genotoxic
    5. Nongenotoxic or Epigenetic Carcinogenesis
    6. Structure–Activity Relationships for Carcinogenic Potential
    7. Short-term Tests for the Determination of Genotoxic and Carcinogenic Potential of Xenobiotics
    8. Biomarkers of Exposure to Carcinogens
    9. Epigenetic Mechanisms and their Toxicological Significance
    10. Reproductive Toxicology
    11. Developmental Toxicology
    12. Developmental Neurotoxicity
    13. Developmental Immunotoxicology
    14. Drug Toxicity in Neonates, Infants and Young Children
    15. Toxicology of the Placenta
    16. Susceptibility of Neonatal Rats to Xenobiotics
  8. Environmental and Ecotoxicology
    1. Air Pollution
    2. Indoor Air Quality
    3. Aquatic Toxicology: Concepts, Practice, New Directions
    4. Environmental Endocrine Toxicology
    5. Assessing Impacts of Environmental Contaminants on Wildlife
    6. Soil and Fresh Water
    7. Biological Criteria for Water Quality in Relation to Human Health
    8. Interactions between Occupational and Environmental Factors in Toxicology, Hazard Evaluation and Risk Assessment
    9. Susceptibility of Children to Environmental Xenobiotics
    10. From Diet to Detox: Controversial Therapies in Autistic Spectrum Disorders
    11. Multiple Chemical Sensitivity: Toxicological Questions and Mechanisms
  9. Specialisation
    1. Clinical Toxicology
    2. Occupational Toxicology
    3. Occupational Toxicology and Occupational Hygiene within the European Union (EU) Chemicals Regulation
    4. Forensic Toxicology
    5. Veterinary Toxicology
    6. Essentials of Epidemiology for Toxicologists
    7. Aviation Toxicology
    8. Space Toxicology: Toxicological Risk Management of Human Health during Space Exploration
    9. The Toxicologist as Expert Witness
  10. Issues Relevant to Toxicology
    1. Regulatory Toxicology
    2. Basic Toxicological Issues in Product-Safety Evaluations
    3. Occupation, Toxic Exposures and Health Effects
    4. Combustion Toxicology and Implications for Adverse Human Health Effects
    5. Biological Correlates of Low-Level Electromagnetic-Field Exposure
    6. Risk Assessment of Chemicals
    7. Toxicogenomics in Risk Assessment
    8. Dose–Response Analysis in Experimental Toxicology and Risk Assessment
    9. Hormesis and Risk Assessment
    10. Chemical Incidents—Emergency Planning, Preparedness, Response and Recovery. Community Considerations
    11. Empirical Methods and Default Approaches in Consideration of Exposure Duration in Dose–Response Relationships
    12. Biomonitoring of the Workplace and Environment
    13. The Role of Poison Centres in Basic and Clinical Toxicology
  11. Professional, Ethical and Legal Issues
    1. Education of the Toxicologist
    2. Ethical, Legal, Social and Professional Issues in Toxicology
    3. Medicolegal and Ethical Issues in the Practice of Toxicology: A British Perspective
    4. Ethical Issues Related to Animal Welfare Considerations in the Toxicology Laboratory
    5. Ethical Issues in Toxic Chemical Hazard Evaluation, Risk Assessment and Precautionary Communications
  12. Military and Homeland Security Toxicology Issues
    1. Toxicology of Chemical Warfare Agents
    2. National and International Aspects on Bioterrorism and Biosecurity
    3. Chemical Terrorism
    4. Evaluating the Long-term Health Consequences of United States Combat Deployments: Toxicology and the Law
    5. Biological Toxins in Warfare and Terrorism
    6. Radiation Terrorism
    7. Depleted Uranium: Toxicology and Health Consequences
    8. Toxicology and Disasters
    9. Long-term Adverse Health Consequences from Exposure to Products Generated from Major Disaster Sites
  13. Toxicology of Specific Groups of Substances
    1. Toxicology of Food Additives
    2. Safety Assessment of Foods Obtained from Crops Developed Using Biotechnology
    3. Biotechnology: Safety Assessment of Biotherapeutics and Agribiotechnology-Derived Foods
    4. Food Allergy and Intolerance
    5. Toxicology of Pesticides
    6. Toxicology of Biocides
    7. Toxicological Considerations for Pharmaceutical Products
    8. Toxicological Considerations in Relation to the Regulatory Safety Evaluation of Medical Devices
    9. Dermal Toxicology of Cosmetics and Body-Care Products
    10. Organic Solvents
    11. Toxicology and Biological Monitoring of Metals
    12. Toxicology of Substances that Affect Performance and Behaviour
    13. Drugs of Addiction in the Domestic, Occupational and Sports Environment
    14. Nanotoxicology—The Toxicology of Nanomaterials
    15. Radiation Toxicology
  14. Toxinology
    1. Poisons of Animal Origin
    2. Poisons of Plant Origin
    3. Mycotoxins with a Special Focus on Aflatoxins, Ochratoxins and Fumonisins
    4. Mycotoxins and Mycotoxicoses: Significance, Occurrence and Mitigation in the Food Chain
    5. Botulism
    6. Ricin: Chemistry, Sources, Exposures, Toxicology and Medical Aspects
  15. Systems Toxicology
    1. Toxicogenomics
      1. Toxicogenomics: An Overview with Special Reference to Genetic and Genomic Approaches to the Identification of Toxic Effects
      2. Toxicogenomics — Applications in Systems Toxicology
      3. System Toxicology Approaches for Evaluating Chemical Carcinogenicity
      4. Effect of p53 Genotype on Gene Expression and DNA Adducts in ENU-Exposed Mice
      5. Application of Ecotoxicogenomics for Understanding Mode of Action of Chemicals and Species Extrapolation
    2. Nutrigenomics
      1. A Community-Based Participatory Research/Translational Biomedical Research Strategy for Personalizing Nutrition, Medicine, and Healthcare
      2. Role of the Endocannabinoid System in Systems Toxicity
    3. Genomic Technology
      1. Integrative Analysis of Microarray Data: A Path for Systems Toxicology
      2. Application of Systems Biology in Neurotoxicological Studies During Development
      3. Mitochondria-Specific Mouse Gene Array and its Application in Toxicogenomics
      4. Integration of Systems Toxicology into Drug Discovery
      5. Systems Toxicology: A Valuable Tool for Early Prediction and Mechanistic Assessment of Liver Toxicity of Food-Related Products
    4. Proteomic Technology
      1. Mass Spectrometry-Based Proteomics in Systems Toxicology
      2. Applications of Proteomic Technologies to Toxicology
      3. Application of Quantitative Proteomic Approaches to Toxicology
      4. Use of Proteomic and Metabolomic Techniques in Ecotoxicological Research
      5. Application of Proteomics to Study Mechanisms of Toxicity and Dose-Response Relationships of Chemical Exposure
    5. Metabolomic Technology
      1. Metabolomics in Systems Toxicology: Towards Personalized Medicine
      2. Species-Metabolite Relation Database KNApSAcK and Its Multifaceted Retrieval System, KNApSAcK Family
      3. Biomarkers for the Assessment of Acetaminophen Induced Liver Injury
      4. Application of Metabonomic Approach in Target Organ Toxicity
    6. Bioinformatics and Chemoinformatics
      1. Toxicoinformatics for Systems Toxicology
      2. Chemoinformatics and its Applications
      3. Biomarker Discovery: Introduction to Statistical Learning and Integrative Bioinformatics Approaches
    7. Systemics
      1. Mechanistic Investigation of EMD335823s Hepatotoxicity Using Multiple Omics Profiling Technologies
      2. Application of DNA Microarray in Studies of Herbal Dietary Supplements
      3. Unravelling Sex Differences in Drug-Induced Liver Injury
      4. Commonality and Stochasticity in Systems Toxicology
      5. Immunotoxicogenomics: A Systems Approach
      6. Systems Biology: Integrating ‘-Omics'-Oriented Approaches to Determine Foodborne Microbial Toxins
      7. Epigenomic Analysis in Toxicology
    8. Image Analysis, Sequencing and Systems Modeling
      1. Sequencing Technology Advances and Toxicology
      2. Next-Generation Sequencing: A Revolutionary Tool for Toxicogenomics
      3. Systems Toxicology Modeling for Prediction in Humans
      4. In Silico Tools for Molecular Modeling
      5. In Silico Toxicology Prediction Using Toxicogenomics Data
      6. Systems Modeling in Developmental Toxicity
      7. Multiscale Integration of Toxicokinetic and Toxicodynamic Processes: From Cell and Tissue to Organ and “Whole Body” Models
      8. Biomarkers of System Response to Therapeutic Intervention
    9. Nanotechnology
      1. Nanotoxicology
      2. Toxicology of Engineered Metal Nanoparticles
      3. Multifunctional Nanomaterials for Biomedical Applications: The Onset of Nanomedicine
      4. Nanotoxicology: A Brief Overview and Discussion of the Current Toxicological Testing In Vitro and Suggestions for Future Research
      5. Toxicity of Selenium Compounds and Nano-Selenium Particles
      6. In Vivo Toxicity Studies of Metal and Metal Oxide Nanoparticles
      7. The Role of Oxidative Stress in Nanotoxicology
      8. Health Effects of Nanoparticles
      9. Systems Toxicological Approach to the Risk Assessment of Nanomaterials
    10. Regulatory Applications
      1. Implementing Systems Toxicology in Drug Development for Regulatory Decision Making