The Liver: Biology and Pathobiology, Fifth Edition

The Liver: Biology and Pathobiology, Fifth Edition

Editor(s): Irwin M. Arias

Published Online: 6 OCT 2009

Print ISBN: 9780470723135

Online ISBN: 9780470747919

DOI: 10.1002/9780470747919

About this Book

In its Fifth Edition, this classic book retains its traditional strength of relating molecular physiology to understanding disease pathology and treatment as it explores the current state and future direction of hepatology.

Painstakingly revised, this edition includes 60 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology. The Fifth Edition's Horizons section includes emerging topics such as tissue engineering of the liver, liver-directed gene therapy, decoding the liver cancer genome, and imaging cellular proteins and structure.

To preserve essential background information which has not changed while making room for the panoply of major new contributions to understanding of liver disease, 14 chapters from the previous edition are freely available online at   To view these chapters visit -

Table of contents

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    1. You have free access to this content
  1. Part One: Introduction

  2. Part Two: The Cells

    1. Chapter 14

      Gap and Tight Junctions in Liver: Composition, Regulation, and Function (pages 201–220)

      Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G. Fort and David C. Spray

  3. Part Two: The Cells - Section A: Hepatocyte

  4. Part Two: The Cells - Section B: Bile Secretion

  5. Part Two: The Cells - Section C: Sinusoidal Cells

  6. Part Three: Interrelated Cell Functions

    1. Chapter 31

      Insulin Resistance (pages 469–483)

      Varman T. Samuel, Kitt F. Petersen and Gerald I. Shulman

    2. Chapter 32

      Ca2+ Signaling in the Liver (pages 485–510)

      Fatima M. Leite, Mateus T. Guerra and Michael H. Nathanson

  7. Part Four: Relation to Other Organs

    1. Chapter 41

      Critical Role of the Liver in Coagulation (pages 639–658)

      Robert Fathke, Ze Peng, Basil Golding and Chava Kimchi-Sarfaty

  8. Part Five: Pathobiological Analysis

  9. Part Six: Horizons

    1. Chapter 56

      Tissue Engineering of the Liver (pages 933–953)

      Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia

    2. Chapter 59

      Liver-Directed Gene Therapy (pages 965–990)

      Betsy T. Kren, Clifford J. Steer, Namita Roy Chowdhury and Jayanta Roy Chowdhury

    3. Chapter 67

      The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions (pages 1091–1103)

      George Kunos, Douglas Osei-Hyiaman, Sándor Bátkai, Pál Pacher, Bin Gao, Won-Il Jeong, Jie Liu and Gregorz Godlewski

    4. Chapter 68

      Telomeres and Aging, Cancer, and Hepatic Fibrosis (pages 1105–1119)

      Hans L. Tillmann, Ruben R. Plentz, Yvonne Begus-Nahrmann, Andrée Lechel and Lenhard K. Rudolph

    1. You have free access to this content