Growth Factors and Psychiatric Disorders: Novartis Foundation Symposium 289

Growth Factors and Psychiatric Disorders: Novartis Foundation Symposium 289

Editor(s): Derek J. Chadwick, Jamie Goode

Published Online: 20 MAY 2008

Print ISBN: 9780470516041

Online ISBN: 9780470751251

DOI: 10.1002/9780470751251

Series Editor(s): Novartis Foundation

About this Book

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.

Table of contents

    1. You have free access to this content
    2. Genetic Variants in Major Depression (pages 23–42)

      Jonathan Flint, Sagiv Shifman, Marcus Munafo and Richard Mott

    3. The Fibroblast Growth Factor Family and Mood Disorders (pages 94–100)

      H. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W. E. Bunney, E. G. Jones and S. J. Watson

    4. Trajectories of Anatomic Brain Development as a Phenotype (pages 101–118)

      Jay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, Francois Lalonde, Mark Celano, Samantha White, Julia Tossell, Anjene Addington and Nitin Gogtay

    5. Neuregulins and Neuronal Plasticity: Possible Relevance in Schizophrenia (pages 165–179)

      Andrés Buonanno, Oh-Bin Kwon, Leqin Yan, Carmen Gonzalez, Marines Longart, Dax Hoffman and Detlef Vullhorst

    6. You have free access to this content
    7. You have free access to this content