Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles

Copyright © 2011 John Wiley & Sons, Inc.

Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles

Editor(s): Flemming R. Cassee, Nicholas L. Mills, David Newby

Published Online: 28 MAR 2011 12:03PM EST

Print ISBN: 9780470433539

Online ISBN: 9780470910917

DOI: 10.1002/9780470910917

About this Book

Product Information

About The Product

This book assists scientists, toxicologists, clinicians, and public health regulators to understand the complex issues that determine the impact of air pollution on the cardiovascular system. It covers a range of relevant topics including particulate matter (PM) sources and characterization, methods of exposure, impact of PM on cells and systems, role of particles in the pathophysiology of cardiovascular disease, risk assessment, and potential environmental and therapeutic interventions.

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xviii)

    1. You have free access to this content
      Color Plates (pages c1–c2)

  3. Part I: Issue Framing

    1. Chapter 1

      Overview (pages 1–22)

      Flemming R. Cassee and Morton Lippmann

    2. Chapter 2

      Acute Effects of Particulate Matter on the Risk of Myocardial Infarction (pages 23–43)

      Krishnan Bhaskaran, Shakoor Hajat and Liam Smeeth

    3. Chapter 3

      Chronic Effects of Air Pollution on Cardiovascular Health (pages 45–57)

      Ranjini M. Krishnan, Joel Kaufman and Gerard Hoek

  4. Part II: Exposure

    1. Chapter 4

      Particle Characterization (pages 59–87)

      Thomas A. J. Kuhlbusch and Christof Asbach

    2. Chapter 5

      Exposure Assessment for Ambient Ultrafine Particles (pages 89–107)

      Timo Lanki, Josef Cyrys, H. -Erich Wichmann and Jeroen de Hartog

    3. Chapter 6

      From Exposure to Dose (pages 109–124)

      Werner Hofmann and Bahman Asgharian

    4. Chapter 7

      Translocation of Inhaled Nanoparticles (pages 125–143)

      Wolfgang G. Kreyling, Winfried Möller, Otmar Schmid, Manuela Semmler-Behnke and Günter Oberdörster

    5. Chapter 8

      Role of Chemical Composition in Determining the Cardiovascular Effects of Particles (pages 145–167)

      Andrew J. Ghio and Yuh-Chin T. Huang

  5. Part III: Methodology

    1. Chapter 9

      In Vitro Studies (pages 169–183)

      Per E. Schwarze and Gerrit M. Alink

    2. Chapter 10

      Experimental Studies in Animals (pages 185–215)

      Urmila P. Kodavanti, Lung-Chi Chen and Daniel L. Costa

    3. Chapter 11

      Human Exposure Studies (pages 217–239)

      Jeremy P. Langrish, Mark W. Frampton and Anders Blomberg

    4. Chapter 12

      Panel Studies (pages 241–248)

      Joel Schwartz

  6. Part IV: Particles and Cardiovascular Disease: Mechanisms A. Atherogenesis

    1. Chapter 13

      Particulates and Oxidative Stress (pages 249–271)

      Steffen Loft, Roel P. F. Schins and Peter Møller

    2. Chapter 14

      Role of Inflammation in the Atherogenic Effects of Particulate Matter (pages 273–285)

      Thomas Sandström and David Newby

    3. Chapter 15

      Inhaled Particles, Postprandial Lipids, and their Possible Contribution to Atherogenesisc: The Trojan Horse Hypothesis (pages 287–293)

      Carlijne Hassing, Maarten J. M. Cramer and Marcel Th. B. Twickler

    4. Chapter 16

      Inhaled Particulate Matter and Atherosclerosis in Humans (pages 295–316)

      Barbara Hoffmann and Nino Künzli

  7. Part IV: Particles and Cardiovascular Disease: Mechanisms B. Vascular Dysfunction

    1. Chapter 17

      Effects of Nanoparticles on the Pulmonary Vasculature (pages 317–350)

      Laurel E. Plummer, Kent E. Pinkerton, Amy K. Madl and Dennis W. Wilson

    2. Chapter 18

      Particulate Matter, Hypertension, and the Metabolic Syndrome (pages 351–377)

      Robert D. Brook and Sanjay Rajagopalan

    3. Chapter 19

      Particles and the Vascular Endothelium (pages 379–402)

      Nicholas L. Mills and Mark R. Miller

  8. Part IV: Particles and Cardiovascular Disease: Mechanisms C. Thrombosis

    1. Chapter 20

      Particles, Coagulation, and Thrombosis (pages 403–420)

      Evren Kilinç, Goran Rudež, Henri M. H. Spronk, Abderrahim Nemmar, Moniek P. M. de Maat, Hugo ten Cate and Marc F. Hoylaerts

    2. Chapter 21

      Particles and the Pathogenesis of Atherothrombosis (pages 421–437)

      Qinghua Sun and Xiaohua Xu

  9. Part IV: Particles and Cardiovascular Disease: Mechanisms D. Arrhythmia

    1. Chapter 22

      Particles and the Autonomic Nervous System (pages 439–466)

      Swapna Upadhyay, Alison Elder, Wayne E. Cascio and Holger Schulz

    2. Chapter 23

      Air Pollution and Arrhythmia (pages 467–482)

      Helen C. Routledge and Jonathan N. Townend

  10. Part V: Environmental and Public Health Policy

    1. Chapter 24

      Risk Assessment (pages 483–496)

      Robert L. Maynard and Jon G. Ayres

    2. Chapter 25

      Environmental Regulation of Particulate Matter (pages 497–523)

      Richard Damberg, Klaas Krijgsheld, May Ajero and Sophie Punte

    3. Chapter 26

      From Ambient Ultrafine Particles to Nanotechnology and Nanotoxicology (pages 525–543)

      Ken Donaldson and David B. Warheit

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      Index (pages 545–585)

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