Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms

Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms

Editor(s): Cheng Wang, William Slikker

Published Online: 15 NOV 2010 09:25AM EST

Print ISBN: 9780470426722

Online ISBN: 9780470917060

DOI: 10.1002/9780470917060

About this Book

This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research.

Table of contents

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    1. You have free access to this content
  1. Section I: Models, Approaches, and Challenges in Neurotoxicity Research during Development

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  2. Section II: Effects of Anesthetics and their Potential Neurotoxicity during Development

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    2. Chapter 5

      Neurotoxic Effects of Anesthetics and Potential Protective Agents (pages 79–93)

      Xuan Zhang, Tucker A. Patterson, Merle G. Paule, William Slikker and Cheng Wang

    3. Chapter 6

      Perinatal Rhesus Monkey Models and Anesthetic-Induced Neuronal Cell Death (pages 95–109)

      William Slikker, Fang Liu, Xuan Zhang, Xiaoju Zou, Tucker A. Patterson, Merle G. Paule and Cheng Wang

  3. Section III: The Developmental Basis of Adolescent or Adult Disease

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  4. Section IV: Risk Assessment of Methyl Mercury and Its Effects on Neurodevelopment

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    2. Chapter 16

      Neurodevelopmental Effects of Maternal Nutrition Status and Exposure to Methyl Mercury from Eating Fish during Pregnancy: Evidence from the Seychelles Child Development Study (pages 319–334)

      Philip W. Davidson, J. J. Strain, Gary J. Myers, Conrad F. Shamlaye, Sally Thurston, Maxine P. Bonham, Emeir M. Duffy, Julie M. W. Wallace, Gene Watson and Thomas W. Clarkson

  5. Section V: Autism Spectrum Disorders

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    2. Chapter 21

      Neurodevelopmental Toxicology and Autism Spectrum Disorders (pages 439–476)

      Robert F. Berman, Claire M. Koenig, Michael R. Hunsaker, Isaac N. Pessah and Janine M. Lasalle

    3. Chapter 22

      Redox Imbalance and the Metabolic Pathology of Autism (pages 477–499)

      Richard Deth, Mostafa Waly, Christina Muratore and Nathaniel Hodgson

  6. Section VI: Strategies and Progress in Epilepsy Research

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    1. You have free access to this content

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