Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques

Copyright © 2011 John Wiley & Sons, Inc.

Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques

Editor(s): Brad Bolon, Mark T. Butt

Published Online: 19 AUG 2011 02:23PM EST

Print ISBN: 9780470227336

Online ISBN: 9780470939956

DOI: 10.1002/9780470939956

About this Book

Product Information

About The Product

This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology - including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Table of contents

    1. You have free access to this content
      Frontmatter (pages i–xx)

    1. You have free access to this content
      Color Plates (pages c1–c32)

  3. Part 1: Fundamentals of Neurobiology

    1. Chapter 1

      Fundamental Neuropathology for Pathologists and Toxicologists: An Introduction (pages 1–14)

      Brad Bolon and Doyle G. Graham

    2. Chapter 2

      Functional Neuroanatomy (pages 15–43)

      Michael H. Stoffel, Anna Oevermann and Marc Vandevelde

    3. Chapter 3

      Atlas of Comparative Neuroanatomy (pages 45–62)

      Anna Oevermann, Marc Vandevelde and Michael H. Stoffel

    4. Chapter 4

      Principles of Comparative and Correlative Neurodevelopment and Their Implications for Developmental Neurotoxicity (pages 63–88)

      Brad Bolon

    5. Chapter 5

      Localizing Neuropathological Lesions Using Neurological Findings (pages 89–103)

      Brad Bolon and Dennis O'Brien

    6. Chapter 6

      Behavioral Model Systems for Evaluating Neuropathology (pages 105–113)

      Virginia C. Moser

    7. Chapter 7

      Cognitive Assessments in Nonhuman Primates (pages 115–123)

      Tucker A. Patterson and Merle G. Paule

    8. Chapter 8

      Impact of Aging on Brain Structure and Function in Rodents and Canines (pages 125–138)

      M. Paul Murphy and Elizabeth Head

    9. Chapter 9

      Fundamentals of Neurotoxicity Detection (pages 139–156)

      Robert C. Switzer

  4. Part 2: Toxicologic Neuropathology: Methodology

    1. Chapter 10

      Practical Neuropathology of the Rat and Other Species (pages 157–170)

      William H. Jordan, Greg Hall, Monty J. Hyten and Jamie K. Young

    2. Chapter 11

      Fluoro-Jade Dyes: Fluorochromes for the Histochemical Localization of Degenerating Neurons (pages 171–179)

      Sumit Sarkar and Larry Schmued

    3. Chapter 12

      Histological Markers of Neurotoxicity (Nonfluorescent) (pages 181–190)

      Robert C. Switzer and Mark T. Butt

    4. Chapter 13

      Common Histological Artifacts in Nervous System Tissues (pages 191–201)

      Robert H. Garman

    5. Chapter 14

      High-Definition Microscopic Analysis of the Nervous System (pages 203–207)

      Bernard S. Jortner

    6. Chapter 15

      Stereological Solutions for Common Quantitative Endpoints in Neurotoxicology (pages 209–228)

      Rogely Waite Boyce, Karl-Anton Dorph-Petersen, Lise Lyck and Hans Jørgen G. Gundersen

    7. Chapter 16

      Anatomy and Processing of Peripheral Nerve Tissues (pages 229–237)

      William Valentine and Brad Bolon

    8. Chapter 18

      In Vivo Imaging Applications for the Nervous System in Animal Models (pages 253–269)

      Kathy Gabrielson, Craig Fletcher, Paul W. Czoty, Michael A. Nader and Tracy Gluckman

    9. Chapter 19

      Cerebrospinal Fluid Analysis in Toxicological Neuropathology (pages 271–283)

      William Vernau, Karen M. Vernau and Brad Bolon

    10. Chapter 20

      Molecular Techniques in Toxicological Neuropathology (pages 285–318)

      Arun R. Pandiri, Stephanie A. Lahousse and Robert C. Sills

    11. Chapter 22

      Pathology Methods in Nonclinical Neurotoxicity Studies: The Developing Central Nervous System (pages 339–363)

      Wolfgang Kaufmann

    1. Chapter 17

      Pathology Methods in Nonclinical Neurotoxicity Studies: Evaluation of Muscle (pages 239–252)

      Beth A. Valentine and John W. Hermanson

  6. Part 3: Toxicological Neuropathology: Current Practices

    1. Chapter 21

      Evaluation of the Adult Nervous System in Preclinical Studies (pages 1–338)

      Mark T. Butt

    2. Chapter 23

      Neuropathological Analysis of the Peripheral Nervous System (pages 365–384)

      Georg J. Krinke

    3. Chapter 24

      Toxicological Pathology of the Retina and Optic Nerve (pages 385–412)

      Meg Ramos, Christopher M. Reilly and Brad Bolon

    4. Chapter 25

      Toxicological Neuropathology of the Ear (pages 413–428)

      Andrew Forge, Ruth Taylor and Brad Bolon

    5. Chapter 26

      Neuropathology of the Olfactory System (pages 429–448)

      Mary Beth Genter and Brad Bolon

  7. Part 4: Applied Toxicological Neuropathology

    1. Chapter 27

      Spinal Delivery and Assessment of Drug Safety (pages 449–462)

      Tony L. Yaksh

    2. Chapter 28

      Diagnostic Neuropathology (pages 463–473)

      Ana Alcaraz and Mark T. Butt

    3. Chapter 29

      Toxicological Neuropathology in Medical Practice (pages 475–486)

      Thomas J. Montine and Douglas C. Anthony

    4. Chapter 30

      Toxicological Neuropathology in Veterinary Practice (pages 487–500)

      Peter B. Little and David C. Dorman

    5. Chapter 31

      Regulatory Considerations in Toxicological Neuropathology (pages 501–504)

      Karl F. Jensen and Kathleen C. Raffaele

    6. Chapter 32

      The Neuropathology Report and the Neuropathology Peer Review Report (pages 506–511)

      Mark T. Butt

    7. Chapter 33

      Preparation of Personnel for Performing Neuropathological Assessment (pages 513–517)

      Jamie K. Young and Mary Jeanne Kallman

    8. Chapter 34

      Regulatory Guide to the Histopathological Assessment of Neurotoxicity Studies (pages 519–535)

      Hope Salvo and Mark T. Butt

    9. Chapter 35

      Toxicological Neuropathology: The Next Two Decades (pages 537–539)

      Brad Bolon and Mark T. Butt

    1. You have free access to this content
      Appendixes: Ready References of Neurobiology Knowledge (pages 541–548)

      Brad Bolon and Doyle G. Graham

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      Appendix 2: Text-Based Neuroanatomic Atlases for Toxicological Neuropathology Studies (page 549)

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      Appendix 3: Text-Based Neurobiology References for Toxicological Neuropathologists (pages 549–550)

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      Appendix 4: Web-Based Neurobiology References for Toxicological Neuropathologists (page 550)

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      Appendix 5: Toxicological Neuropathology References for Nervous System Targets (page 551)

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      Appendix 6: Comparative and Correlative Neurobiological Parameters for the Brain (pages 551–554)

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      Appendix 7: Comparison of Relative Proportions in the Brain and Spinal Cord Regions of Humans and Rats (page 554)

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      Appendix 8: Chemical Composition of Central Nervous System Tissues and Fluids (pages 555–562)

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      Index (pages 563–590)

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