Platelet Proteomics: Principles, Analysis, and Applications

Platelet Proteomics: Principles, Analysis, and Applications

Editor(s): Ángel García, Yotis A. Senis

Published Online: 12 JUL 2011 12:45PM EST

Print ISBN: 9780470463376

Online ISBN: 9780470940297

DOI: 10.1002/9780470940297

Series Editor(s): Dominic M. Desiderio, Nico M. M. Nibbering

About this Book

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.  This chapter shows potential applications for platelet proteomics not yet carried out.  It includes examples of post-translational modifications (PTMs) analysis in platelets.

The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease.  This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Table of contents

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  1. Part I: General Overview: Platelets, Sample Preparation, and Mass Spectrometry-Based Proteomics

  2. Part II: Analysis of the Platelet Proteome: Global Approaches and Subproteomes

  3. Part III: Integrated “Omics” and Application to Disease

    1. Chapter 11

      Platelet Functional Genomics (pages 253–284)

      Isabelle I. Salles, Marie N. O'Connor, Daphne C. Thijssen-Timmer, Katleen Broos and Hans Deckmyn

    2. Chapter 14

      Cardiovascular Proteomics (pages 341–379)

      Fernando Vivanco, Fernando de la Cuesta, María G. Barderas, Irene Zubiri and Gloria Álvarez-Llamas

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