Chemical Synthetic Biology

Copyright © 2011 John Wiley & Sons, Ltd

Chemical Synthetic Biology

Editor(s): Pier Luigi Luisi, Cristiano Chiarabelli

Published Online: 14 FEB 2011 01:48AM EST

Print ISBN: 9780470713976

Online ISBN: 9780470977873

DOI: 10.1002/9780470977873

About this Book

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About The Product

Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.

Table of contents

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      Front Matter (pages i–xi)

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      Colour Plates (pages c1–c4)

    1. Introduction (pages 1–4)

      Pier Luigi Luisi

  4. Part One: Nucleic Acids

    1. Chapter 1

      Searching for Nucleic Acid Alternatives (pages 5–45)

      Albert Eschenmoser

    2. Chapter 2

      Never-Born RNAs: Versatile Modules for Chemical Synthetic Biology (pages 47–67)

      Davide De Lucrezia, Fabrizio Anella, Cristiano Chiarabelli and Pier Luigi Luisi

    3. Chapter 3

      Synthetic Biology, Tinkering Biology, and Artificial Biology: A Perspective from Chemistry (pages 69–106)

      Steven A. Benner, Fei Chen and Zunyi Yang

    4. Chapter 4

      Peptide Nucleic Acids (PNAs) as a Tool in Chemical Biology (pages 107–118)

      Peter E. Nielsen

  5. Part Two: Peptides and Proteins

    1. Chapter 5

      High Solubility of Random-Sequence Proteins Consisting of Five Kinds of Primitive Amino Acids (pages 119–137)

      Nobuhide Doi, Koichi Kakukawa, Yuko Oishi and Hiroshi Yanagawa

    2. Chapter 6

      Experimental Approach for Early Evolution of Protein Function (pages 139–153)

      Hitoshi Toyota, Yuuki Hayashi, Asao Yamauchi, Takuyo Aita and Tetsuya Yomo

    3. Chapter 7

      Searching for de novo Totally Random Amino Acid Sequences (pages 155–174)

      Cristiano Chiarabelli, Cecilia Portela Pallares and Anna Quintarelli

  6. Part Three: Complex Systems

    1. Chapter 8

      Synthetic Genetic Codes as the Basis of Synthetic Life (pages 175–199)

      J. Tze-Fei Wong and Hong Xue

    2. Chapter 9

      Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids (pages 201–226)

      Piet Herdewijn and Philippe Marliere

    3. Chapter 10

      The Minimal Ribosome (pages 227–245)

      Hiroshi Yamamoto, Markus Pech, Daniela Wittek, Isabella Moll and Knud H. Nierhaus

    4. Chapter 11

      Semi-Synthetic Minimal Living Cells (pages 247–286)

      Pasquale Stano, Francesca Ferri and Pier Luigi Luisi

  7. Part Four: General Problems

    1. Chapter 12

      Replicators: Components for Systems Chemistry (pages 287–319)

      Olga Taran and Günter von Kiedrowski

    2. Chapter 13

      Dealing with the Outer Reaches of Synthetic Biology Biosafety, Biosecurity, IPR, and Ethical Challenges of Chemical Synthetic Biology (pages 321–342)

      Markus Schmidt, Malcolm Dando and Anna Deplazes

    3. Chapter 14

      The Synthetic Approach in Biology: Epistemological Notes for Synthetic Biology (pages 343–362)

      Pier Luigi Luisi

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      Index (pages 363–372)

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